Serotonin-1A (5-HT(1A)) receptors in the CNS are a major target for psychotropic drugs. In nucleus raphe dorsalis (NRD) and hippocampus (CA3), the selective 5-HT(1A) agonist (+)-8-hydroxy-2-(di-N-propylamino) tetralin (8-OH-DPAT) reduces the firing activity of serotoninergic (5-HT) and pyramidal neurons, respectively. When located on 5-HT (autoreceptors), but not on non-5-HT (heteroreceptors) n...

Valaciclovir, the L-valyl ester of acyclovir (ZOVIRAX), demonstrated good oral absorption and nearly complete conversion to acyclovir in cynomolgus monkeys, indicating its suitability as an orally administered prodrug. The major urinary metabolites of [8-14C]valaciclovir, administered orally (10 and 25 mg/kg) or intravenously (10 mg/kg) to male monkeys, were acyclovir (46%-59% of urinary radioa...

STUDY OBJECTIVE To assess concentrations of morphine and its metabolites after patient-controlled analgesia (PCA). DESIGN Pilot pharmacokinetic study of morphine and pharmacokinetic simulation. SETTING Post-anesthesia care room and ward of an academic teaching hospital. PATIENTS 10 ASA physical status I, II, and III postoperative surgical patients. INTERVENTIONS Patients received morphi...

The purpose of this study was to compare heart rate (HR) responses within and between physical controlled (short-duration intermittent running) and physical integrated (sided games) training methods in elite soccer players. Ten adult male elite soccer players (age, 26 +/- 2.9 years; body mass, 78.3 +/- 4.4 kg; maximum HR [HRmax], 195.4 +/- 4.9 b x min(-1) and velocity at maximal aerobic speed (...

The bed nucleus of the stria terminalis (BST) has been known to contain estrogen (E)-concentrating neurons. In addition, injections of E into BST have been reported to potentiate the sympathoinhibitory arterial pressure (AP) and heart rate (HR) responses elicited by glutamate (Glu) stimulation. In this study, the effect of glutamate antagonist receptors in the rostral ventrolateral medulla (RVL...

METHODS Twenty-eight Korean women were treated using hair removal (HR) (600–950 nm filter) and 27 using HR-D (645–950 nm filter) in the axillary area. Four treatments were carried out at intervals of 4 to 6 weeks; follow-ups were conducted 8 months after the last treatment. Mean energy settings were 14.9 2.0 J/cm2 for HR and 17.1 0.6 J/cm2 for HR-D. Longer pulse widths were applied in case of H...