myelodysplastic syndrome (mds), is a group of heterogeneous disorders of hematopoietic stem cell colonies which is determined by incomplete hematopoiesis in one or more cell lines. the incidence increases with age and it has less been reported among patients under 50 years of age. the commonest form of mds is sporadic, and familial occurrence of mds is rare. patients with familial mds are young...

The estrogen 17β‑estradiol has been proven to serve an indispensable role in the occurrence and development of adenomyosis (ADS). let‑7a/Lin28B axis can control cell proliferation by acting as a tumor‑inhibiting numerous types cancer. However, its ADS remains unknown. present study aimed i) elucidate let‑7a regulating human uterine junctional zone (JZ) smooth muscle cells (SMCs) ADS, ii) evalua...

Myelodysplastic syndrome (MDS), is a group of heterogeneous disorders of hematopoietic stem cell colonies which is determined by incomplete hematopoiesis in one or more cell lines. The incidence increases with age and it has less been reported among patients under 50 years of age. The commonest form of MDS is sporadic, and familial occurrence of MDS is rare. Patients with familial MDS are young...

To locate the genes controlling adaptability in bread wheat using AMMI (additive main effect and multiplicative interaction) model, twenty-one substitution lines derived from the parents Chinese Spring (recipient) and Chayan (donor) were used in a randomized complete block design with three replications in three different environments in the Agricultural College of Razi University, Kermanshah, ...

We report on the relationship between the structure-pharmacokinetics, metabolism, and therapeutic activity of semisynthetic bile acid analogs, including 6a-ethyl-3a,7a-dihydroxy-5b-cholan-24-oic acid (a selective farnesoid X receptor [FXR] receptor agonist), 6a-ethyl-23(S)-methyl-3a,7a,12a-trihydroxy-5b-cholan-24-oic acid (a specific Takeda G protein–coupled receptor 5 [TGR5] receptor agonist),...

7or-(4'-Amino)phenylthio-l,4-androstadiene-3,17-dione(7a-APTADD), a potent enzyme-activated irreversible inhibitor, was examined in two different human cell culture lines, MCF-7 human mammary carcinoma cells and JAr choriocarcinoma cells. Both the MCF-7 and JAr cell culture systems exhibit aromatase activity, and 7a-APTADD was evaluated for its aromatase-inhibitory activity, for its ability to ...

in view of potential biological activities of small molecule polyamides, we synthesized some novel n-(2-aminoethyl)-1-benzyl-2- (alkylthio)-1h-imidazole-5-carboxamide (7a,b), and n-(2-(1-benzyl-2-(alkylthio) -1h-imidazole- 5-carboxamido) ethyl)-1-benzyl-2- (alkylthio)-1h-imidazole-5-carboxamides (8a,b) as antitumor agents. the antitumor activity of compounds 7a,b and 8a,b was studied at concent...

MicroRNAs (miRs) are small noncoding RNA sequences that negatively regulate the expression of target genes by posttranscriptional repression. miRs are dysregulated in various diseases, including cancer. let-7a miR, an antioncogenic miR, is downregulated in lung cancers. Our earlier studies demonstrated that let-7a miR inhibits tumor growth in malignant pleural mesothelioma (MPM) and could be a ...

7or-(4'-Amino)phenylthio-l,4-androstadiene-3,17-dione(7a-APTADD), a potent enzyme-activated irreversible inhibitor, was examined in two different human cell culture lines, MCF-7 human mammary carcinoma cells and JAr choriocarcinoma cells. Both the MCF-7 and JAr cell culture systems exhibit aromatase activity, and 7a-APTADD was evaluated for its aromatase-inhibitory activity, for its ability to ...

The synthesis of novel amide derivatives of benzosuberone 7a-j from commercially available benzosuberone was successfully achieved in six steps. Some of the important reactions that are involved in the synthesis are (i) insertion of methylester (ii) Suzki reaction and (iii) saponification followed by amide bond formation. The newly synthesis benzosuberone derivatives 7a-j were screened for anti...