Seasonal changes in plasma levels of testosterone (T) and 5α-dihydrotestosterone (DTH) were examined in the adult male Japanese red-bellied newt. The concentration of plasma T increased significantly (p<0.05) from January to February and decreased drastically from April to July when it reached its minimum. After the summer decline, plasma T increase rapidly from July to October (p<0.05) and rea...

Abstract Triple negative breast cancer (TNBC) has poor prognosis and neither established biomarkers nor therapeutic targets. On the one hand androgen receptor (AR), a steroid hormone (SR) which is expressed in 10-53% of TNBC proved to be critical for BC proliferation, been proposed as new target TNBC. other hand, we others have shown that membrane ErbB-2 migrates nucleus (nuclear ErbB-2, NErbB-...

Three [35S|methionine-labeled polypeptides released by T47D human breast cancer cells have been identified as corresponding to two proteins previously described in breast gross cystic disease fluid. A M, 43,000 protein was immunoprecipitated by polyclonal antibodies to the 7,n-«2glycoprotein. A M, 18,000 and a M, 13,000 polypeptide were both immunoprecipitated by four monoclonal antibodies dir...

The gender-specific differences in body fat distribution suggest that sex steroids play an important role in regulating body fat distribution. Sex steroids may regulate adipose tissue mass by altering adipocyte number and size. The effects of various sex steroids on in vitro proliferation of preadipocytes from both sc and omental fat depots was investigated in men and women. Abdominal sc and om...

Steroid 5α-reductase is the enzyme that converts testosterone to 5α-dihydrotestosterone (DHT). Two isoenzymes have been identified, namely type 1 and type 2 [1]. The conversion of testosterone to DHT is irreversible and the androgenic potency of DHT was shown to be at least 2–5 times stronger than that of testosterone [2, 3]. The hyperactivity of this enzyme is, therefore, supposed to play an i...

Katsevich formula is currently a hot topic for cone-beam computed tomography (CBCT). The filter in the formula can be computed by a regular discrete Hilbert transform (DHT). A configurable single precision floating-point (SPFP) DHT processor is proposed for accelerating the calculation of filter in Katsevich formula. The configurable processor is of memory based architecture with one pipelined ...

Circulating dehydroepiandrosterone (DHEA) is converted to testosterone or estrogen in the target tissues. Recently, we demonstrated that skeletal muscles are capable of locally synthesizing circulating DHEA to testosterone and estrogen. Furthermore, testosterone is converted to 5alpha-dihydrotestosterone (DHT) by 5alpha-reductase and exerts biophysiological actions through binding to androgen r...

The cardiovascular effect of estrogen is currently under intense investigation, but the role of androgens in vascular biology has attracted little attention. Because endothelial repair and vascular smooth muscle cell (VSMC) proliferation affect atherogenesis, we analyzed the effects of 17beta-estradiol (E2), dihydrotestosterone (DHT), and sex hormone antagonists on DNA synthesis in human umbili...

DQ-DHT is a resource discovery algorithm that combines the Dynamic Querying (DQ) technique used in unstructured peer-to-peer networks with an algorithm for efficient broadcast over a Distributed Hash Table (DHT). Similarly to DQ, DQ-DHT dynamically controls the query propagation on the basis of the desired number of results and the popularity of the resource to be located. Differently from DQ, ...

Androgens act to stimulate spermatogenesis through androgen receptors (ARs) on the Sertoli cells and peritubular myoid cells. Specific ablation of the AR in either cell type will cause a severe disruption of spermatogenesis. To determine whether androgens can stimulate spermatogenesis through direct action on the peritubular myoid cells alone or whether action on the Sertoli cells is essential,...