نتایج جستجو برای: 50 percent r

تعداد نتایج: 954687  

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2015
Raul D Santos Frederick J Raal Alberico L Catapano Joseph L Witztum Elisabeth Steinhagen-Thiessen Sotirios Tsimikas

OBJECTIVE Lp(a) is an independent, causal, genetic risk factor for cardiovascular disease and aortic stenosis. Current pharmacological lipid-lowering therapies do not optimally lower Lp(a), particularly in patients with familial hypercholesterolemia (FH). APPROACH AND RESULTS In 4 phase III trials, 382 patients on maximally tolerated lipid-lowering therapy were randomized 2:1 to weekly subcut...

2003
Brett R. Gordon Uday Rajan

From 1995 to 1998, more than 90 percent of mid-range IPOs were charged underwriter fees, or spreads, of exactly seven percent, even though evidence suggests that economies of scale in the size of the offering should allow for lower fees. Chen and Ritter (2000) offer collusion as a possible explanation based on empirical analysis and observation. Alternatively, we investigate whether the spreads...

Journal: :Publications of the Astronomical Society of the Pacific 2002

Journal: :The Yale Journal of Biology and Medicine 1984
G. P. Schmid A. G. Steigerwalt S. Johnson A. G. Barbour A. C. Steere I. M. Robinson D. J. Brenner

Lyme disease spirochetes (LDS) have phenotypic characteristics of both treponemes and borreliae. To ascertain whether one or more species of LDS exist, as well as their taxonomic status, we determined the DNA base (G + C) content for three strains of LDS, the DNA relatedness of ten strains isolated in the United States or Europe, and the DNA relatedness of LDS to other spirochetes. The G + C co...

Journal: :Chest 1983
K R Chapman A D'Urzo A S Rebuck

We evaluated the accuracy and speed of response of a newly available, lightweight, and relatively inexpensive ear oximeter (Biox II oximeter). The instrument was compared with another oximeter (Hewlett-Packard 47201A) under conditions of both steadily maintained and progressively increasing hypoxia induced in normal subjects by rebreathing. The new oximeter (Biox II), which can be operated in e...

Journal: :Antimicrobial agents and chemotherapy 2010
David Croteau Scott Letendre Brookie M Best Ronald J Ellis Sheila Breidinger David Clifford Ann Collier Benjamin Gelman Christina Marra Gilbert Mbeo Allen McCutchan Susan Morgello David Simpson Lauren Way Florin Vaida Susan Ueland Edmund Capparelli Igor Grant

HIV-associated neurocognitive disorders continue to be common. Antiretrovirals that achieve higher concentrations in cerebrospinal fluid (CSF) are associated with better control of HIV and improved cognition. The objective of this study was to measure total raltegravir (RAL) concentrations in CSF and to compare them with matched concentrations in plasma and in vitro inhibitory concentrations. E...

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