نتایج جستجو برای: 5 fluorophenyl 1

تعداد نتایج: 3371655  

2008
Ying Li Yong-Qiang Ma Zi-Ning Cui Xin-Ling Yang Yun Ling

The title compound, C(19)H(12)F(3)NO(4), was synthesized by the reaction of 5-(4-fluoro-phen-yl)-2-furan-methanol and 2,6-difluoro-benzoyl-isocyanate. The seven atoms of the fluorophenyl group are disordered over two positions with site occupancy factors ca 0.6 and 0.4. The dihedral angle between the furan and fluorophenyl rings is 1.58°. In the crystal structure, the mol-ecules are linked via ...

Journal: :Acta Crystallographica Section E Structure Reports Online 2010

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2011
Anthony G Borel Timothy M Jones Robert J Barbuch David A Jackson Palaniappan Kulanthaivel Edward Mattiuz Valentine J Klimkowski William J Wheeler Gregory A Rener

2-Methylalanyl-N-{1-[(1R)-1-(4-fluorophenyl)-1-methyl-2-oxo-2-pyrrolidin-1-ylethyl]-1H-imidazol-4-yl}-5-phenyl-D-norvalinamide (LY654322) was rapidly cleared in rats and dogs by renal excretion of parent and metabolism (oxidative and hydrolytic). Among the metabolites identified in the urine of rats and dogs was M25, which was structurally unusual. Indeed, the characterization of M25 and invest...

Journal: :Current issues in pharmacy and medicine: science and practice 2019

Journal: :Acta Crystallographica Section E Structure Reports Online 2011

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