carbon paste electrode was modified by disodium 2,4-diamino-7-methylbenzo[g] pteridine-5,10-dioxide to fabricate a sensor for potentiometric determination of vanadyl ion (vo2+) in aqueous medium. the new ligand was synthesized in three steps with high yield. the optimal composition of the carbon paste was made of graphite powder (64.5%), ionophore (16.6%), paraffin oil (17.8%), and sodium tetra...

Dimethyl sulfoxide (DMSO) is widely used as a solvent in organic synthesis and pharmacology because of its low cost, stability, non-toxicity. Multicomponent reactions are powerful synthetic tool for the rapid efficient construction complicated molecular frameworks. In this communication, multicomponent transformation salicylaldehyde, malononitrile dimer, dimethyl malonate DMSO at room temperatu...

The DNA repair enzyme NEIL1 is a DNA glycosylase that is involved in the first step of base excision repair (BER) of oxidatively induced DNA damage. NEIL1 exhibits a strong preference for excision of 4,6-diamino-5-formamidopyrimidine (FapyAde) and 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua) from DNA with no specificity for 8-hydroxyguanine (8-OH-Gua). In this study, we report on the s...

Abstract Since the first synthesis of 2,6-diamino-3,5-dinitropyrazine-1-oxide (LLM-105) in Lawrence Livermore National Laboratory (LLNL) America 1993, efforts investigation into LLM-105 have never ended due to its premium performance. Therefore, with goal further emphasize importance this material and provide reference application propellants explosives, properties performance are briefly intro...

The triazine WR99210 [4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(2,4,5-trichlorophenoxypropyloxy)-1,3,5 triazine] inhibits Toxoplasma gondii in vitro at nanomolar levels (P < 0.05). The 50% inhibitory concentration (IC(50)) was approximately 50 nM. It is a potent inhibitor in vitro and is also effective in vivo. Administration of WR99210 parenterally (i.e., intraperitoneally) reduced the mean numb...

The structure of a new antibiotic, CV-1 was determined to be 1,2-diamino-1,2-N,N'-carbonyl-1,2-dideoxy-alpha-D-glucose hydrate by spectral and chemical studies. CV-1 possessed a unique open ring hemiaminal structure. CV-1 synthesized from N-carbamoyl-D-glucosamine was identical to material isolated from fermentation.

We investigated whether phorbol-12-acetale-13-myristate (PMA)-activated human polymorphonuclear leukocytes (PMNs) induce base modifi cations in target cell DNA in vivo. Human PMNs produced 9.4 ±0.8 (SD) ninol of l M >71(>''cells during 50 min of exposure to 2 ug/ml I'M A and 13.7 ±2.8 iiini)l/l(l'' cells during exposure to I'M V plus 5 uni N;iN,. Neither nonstimulated PMNs, nor PMA alone, nor...