During early Drosophila embryogenesis, several zygotic gene products act to establish a posttranscriptional activity gradient of the morphogen DPP. Among these molecules, Tolloid, a putative metalloprotease related to BMP-1, enhances DPP function, while SOG, an ortholog of the Xenopus organizer Chordin, inhibits DPP function. Using epistasis tests and a Xenopus secondary axis induction assay, w...

Alterations in dipeptidyl peptidase-IV (DPP-IV) enzymatic activity are characteristic of malignant transformation. Through its well-characterized functionality in regulating the activity of bioactive peptides by removal of the N-terminal dipeptide, DPP-IV activity may have profound effects upon metastatic potential and cell growth. Although DPP-IV/CD26 (EC 3.4.14.5) is the canonical representat...

In Drosophila, a BMP-related ligand Decapentaplegic (Dpp) is essential for cell fate specification during embryogenesis and in imaginal disc development. Dpp signaling culminates in the phosphorylation and nuclear translocation of Mothers against dpp (Mad), a receptor-specific Smad that can bind DNA and regulate the transcription of Dpp-responsive genes. Genetic analysis has implicated Schnurri...

INTRODUCTION Evaluation of interventions can help to close the gap between research and practice but seldom takes place during implementation. Using the RE-AIM framework, we conducted a formative evaluation of the first year of the Intermountain Healthcare Diabetes Prevention Program (DPP). METHODS Adult patients who met the criteria for prediabetes (HbA1c of 5.70%-6.49% or fasting plasma glu...

A simple and highly sensitive voltammetric method was developed for the determination of benazepril (I) and ramipril (II). The compounds were treated with nitrous acid, and the cathodic current produced by the resulting nitroso derivatives was measured. The voltammetric behavior was studied by adopting direct current (DCt), differential pulse (DPP), and alternating current (ACt) polarography. B...

Dipeptidyl peptidase-4 (DPP-4) inhibitors are a newer class of oral hypoglycemic medications which prevent the breakdown of incretin, resulting in decreased glucagon levels and increased insulin release, thereby reducing blood glucose. This medication class is primarily indicated for management of type 2 diabetes as either monotherapy or in combination with other oral hypoglycemic agents.1-4 Th...

SUMMARY Between 1358 to 1371, 32711 patients were visited in the private chinic of first author. Among them, 7935 patients (24 percent) have had low back and I or sciatica. 93 percent of patients in the last group responded to conservative treatment, but 544 cases who resisted to medical treatment were operated. Existing data in their files were analysed. The most common symptom was pain (99, ...

Science sometimes moves very slowly. Observations in 1964 (1,2) that the insulin response to oral (and enteral) glucose is substantially greater than that to an isoglycemic intravenous glucose infusion (the incretin effect), followed by characterization of the two known incretin hormones, glucose-dependent insulinotropic polypeptide (GIP) (1973) and glucagon-like peptide 1 (GLP-1) (1985), have ...

A 5 percent of family physicians and 7 percent of all physicians are sued for malpractice in the United States each year, according to a recent study. The incidence of lawsuits is much greater in some surgical subspecialties, with annual rates approaching 20 percent among neurosurgeons and cardiothoracic surgeons. For low-risk specialties including family medicine, the annual incidence of claim...

to study the effect of different harvesting intensity on forage production of bromus tomentellus was considered of majid abad qorveh. treatments included four harvested intensity 25, 50 and 75 percent and control (no harvest).data were analyzed based on splitplot over time during four years(1386-1389) using sas and irristat software. the results showed that the main effect of year, different ha...