نتایج جستجو برای: 5 سیناپتوزوم

تعداد نتایج: 1215769  

Journal: :the iranian journal of pharmaceutical research 0
maqsood ahmad college of pharmacy gc university faisalabad. shazia akram ghumman department of pharmacy university of sargodha, sargodha, pakistan. alam geer department of pharmacy university of sargodha, sargodha, pakistan. tanveer sharif college of pharmacy gc university faisalabad. muhammad sher department of pharmacy university of sargodha, sargodha, pakistan. tahir abbas department of zoology university of punjab, pakistan.

several modalities of drug administration have been investigated to improve bioavailability and to reduce 5-fu related toxicity. the aim of present study was to evaluate the effect of skimmed milk on the absorption and metabolism of 5-fu in rabbits, mice and dogs. it was further aimed to determine its route related toxicity in rabbits.    plasma concentration of both 5-fu and its metabolite 5-f...

Journal: :Bulletin of the Chemical Society of Japan 1966

Journal: :Zeitschrift fur Naturforschung. Section C, Biosciences 1984
P Lassota R Stolarski D Shugar

Susceptibilities to snake venom 5'-nucleotidase (EC 3.1.3.5) have been evaluated for several 8-substituted analogues of 5'-GMP with varying populations of syn/anti conformations about the glycosidic bond. Improved syntheses of some of these are described, including direct chlorination of 5'-GMP to give 8-chloro-5'-GMP, a procedure which should be applicable to other purine nucleotides. The conf...

2016
Rui Wang Zhipu Luo Kaizhang He Michael O. Delaney Doris Chen Jia Sheng

5-Formylcytidine (f(5)C), a previously discovered natural nucleotide in the mitochondrial tRNA of many species including human, has been recently detected as the oxidative product of 5-methylcytidine (m(5)C) through 5-hydroxymethylcytidine (hm(5)C) in total RNA of mammalian cells. The discovery indicated that these cytosine derivatives in RNA might also play important epigenetic roles similar a...

2013
Amritraj Patra Joel Harp Pradeep S. Pallan Linlin Zhao Mikhail Abramov Piet Herdewijn Martin Egli

The thymine analog 5-chlorouridine, first reported in the 1950s as anti-tumor agent, is known as an effective mutagen, clastogen and toxicant as well as an effective inducer of sister-chromatid exchange. Recently, the first microorganism with a chemically different genome was reported; the selected Escherichia coli strain relies on the four building blocks 5-chloro-2'-deoxyuridine (ClU), A, C a...

Journal: :Restorative neurology and neuroscience 2012
Hu Chen Svetlana Dzitoyeva Hari Manev

PURPOSE Aging is believed to affect epigenetic marking of brain DNA with 5-methylcytosine (5mC) and possibly via the 5mC to 5-hydroxymethylcytosine (5hmC) conversion by TET (ten-eleven translocation) enzymes. We investigated the impact of aging on hippocampal DNA 5-hydroxymethylation including in the sequence of aging-susceptible 5-lipoxygenase (5-LOX) gene. METHODS Hippocampal samples were o...

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