The 1,3-dipolar cycloaddition reactions of the electron deficient boron azide, (C6F5)2BN3 (1) with the electron-poor acetylenes RO2CC≡CCO2R (R = Me, Et) afforded the new mono- and bis-1,2,3-triazole derivatives and .

Epilepsy is the most frequent nearological affiction and afflicts 1% about of the world's population. Currently there is an urgent need for the development of novel anticonvulsants with higher levels of potency and lower levels of toxicity. In this paper, a series of new 6-(substituted-phenyl)thiazolo[3,2-b][1,2,4]triazole derivatives were synthesized and tested for their anticonvulsant activit...

C-5 alkynylated and N-1 alkylated pyrimidine derivatives were synthesized by N-alkylation reaction of 5-iodouracil in the presence of NaH, as a base, followed by Pd-catalyzed Sonogashira cross-coupling reaction of N-alkyl-5-iodouracil derivatives (1 and 2) with corresponding terminal alkynes. Intramolecular in situ O-heteroannulation ring closure of N-1-alkyl-C-5-alkynylpyrimidine derivatives (...

The 1,2,3-Triazole derivatives containing the sulfonyl group have proved their biological importance in medicinal chemistry and drug design. In this sense, we describe regioselective synthesis of 2-(phenylsulfonyl)-2H-1,2,3-triazole 3 good yield through a classical sulfonamidation reaction 1H-1,2,3-triazole 1 with benzenesulfonyl chloride 2 dichloromethane using slight excess triethylamine at 2...

The development of heterocyclic scaffolds is a fast emerging subject in the medicinal chemistry. Imidazole, triazole, benzimidazole and their fused compounds are extensively studied because of their significant pharmacological activities 1 . Another class of heterocyclic scaffolds containing nitrogen, oxygen and sulphur with eminent biological activities in central nervous system is dibenzothia...

The olefin moiety presents in styrylsulfonylmethyl-1,2,4-triazolylamine (1) was exploited to build up five-member heterocycle-pyrazoles. series of novel pyrazolyl-1,2,4-triazole amine derivatives (2-3) have been synthesized. All the entitles compounds were characterized by 1H and 13C NMR spectra.

the synthesis of 3-amino-1-nitroguanidine (3-anq) and 5-hydrazino tetrazole (5-ht) derivatives as new energetic materials are described. reaction of 3-anq with triethyl orthoformate leads to the formation of 3-nitramino triazole while no reaction was observed whit 5-ht. addition of nan3 to a mixture of 3-anq and triethyl orthoformate, afforded 1-nitroguanidyl tetrazole in excellent yield. on th...