BACKGROUND Stage III unresectable non-small cell lung cancer (NSCLC) is preferably treated with concurrent schedules of chemoradiotherapy, but none is clearly superior Gemcitabine is a radiosensitizing cytotoxic drug that has been studied in phase 1 and 2 studies in this setting. The aim of this study was to describe outcome and toxicity of low-dose weekly gemcitabine combined with concurrent 3...

PURPOSE The present project studied the implications of using the irregular surface compensator (ISC) technique in comparison to three-dimensional conformal radiation therapy (3D-CRT) for breast cancer treatment. ISC is an electronic compensation algorithm that modulates the fluence across the radiation fields to compensate for irregularly-shaped surfaces and deliver a homogeneous dose to a com...

OBJECTIVES Although Gadolinium enhanced bFFE is commonly used to evaluate cisternal tumors, banding artifact may interrupt interpretation and adjacent nerve and vessels differentiation is known to be difficult. We analyzed the qualities of Gd enhanced 3D PDDE in the evaluation of cisternal tumors, comparing with bFFE. MATERIAL AND METHODS Forty five cisternal tumors (33 schwannoma and 12 meni...

BACKGROUND The purpose of this study was to assess the impact on dose to the planning target volume (PTV) and organs at risk (OAR) by using four differently generated CT datasets for dose calculation in stereotactic body radiotherapy (SBRT) of lung and liver tumors. Additionally, dose differences between 3D conformal radiotherapy and volumetric modulated arc therapy (VMAT) plans calculated on t...

Abstract Cancer cell spheroids are the simplest 3D in vitro cancer models and have been extensively used for research. More recently, becoming complex, with introduction of a matrix non-cancer types to mimic specific tumour aspects. However, applying drugs or agents matrix-embedded can be problematic. Most matrices impede also bind visualizing non-specifically, vicinity embedded spheroids. This...

OBJECTIVES The aim of this study was to develop a 3-dimensional (3D) fusion tool kit to integrate left ventricular (LV) venous anatomy on fluoroscopy venograms with LV epicardial surface on single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) for guiding cardiac resynchronization therapy (CRT) LV lead placement. BACKGROUND LV lead position is important for CRT...

BACKGROUND The specific aim of this study is to evaluate the cost-effectiveness of intensity-modulated radiation therapy (IMRT) compared with three-dimensional conformal radiation therapy (3D-CRT) in the treatment of a 70-year-old with intermediate-risk prostate cancer. METHODS A Markov model was designed with the following states; posttreatment, hormone therapy, chemotherapy, and death. Tran...

Introduction: Cardiac resynchronization therapy (CRT) has proved successful in larger patient populations as an adjunctive therapy for patients with drug-refractory heart failure and ventricular conduction delay. However, individual responsiveness to CRT is not yet highly predictable. Around 30% of patients do not appear to benefit from CRT [1]. This can either be attributed to inappropriate pa...

BACKGROUND To integrate 3D MR spectroscopy imaging (MRSI) in the treatment planning system (TPS) for glioblastoma dose painting to guide simultaneous integrated boost (SIB) in intensity-modulated radiation therapy (IMRT). METHODS For sixteen glioblastoma patients, we have simulated three types of dosimetry plans, one conventional plan of 60-Gy in 3D conformational radiotherapy (3D-CRT), one 6...

Cardiac resynchronization therapy (CRT) can alleviate left ventricular (LV) electrical dyssynchrony mediated systolic heart failure (HF). Prolonged baseline QRS duration (QRSd) is the only conventional quantitative ECG criteria to assess dyssynchrony. Evaluate voltage-time-integral (VTI), along with QRSd, and their reduction effect after CRT as predictors of future HF events. We included 595 pa...