The aim of the present study was to investigate regulatory relationships among hypoxia-inducible factor-1α (HIF-1α), microRNA and erythroid transcription factors. K562 cells were transfected with HIF-1α knockout or with overexpression lentivirus of plasmid (MOI 10). The cells were divided into 3 groups: the negative control, overexpressing and interference groups. The cells were cultured under ...

Placental insufficiency leading to intrauterine growth restriction (IUGR) demonstrates perturbed gene expression affecting placental angiogenesis and nutrient transfer from mother to fetus. To understand the post-transcriptional mechanisms underlying such placental gene expression changes, our objective was to identify key non-coding microRNAs that express biological function. To this end, we i...

II. THE TROUBLE WITH AI ............................................................... 358 A. What Is AI? ............................................................................... 359 B. The Problematic Characteristics of AI .................................... 362 1. Autonomy, Foreseeability, and Causation ............................ 363 2. Control ........................................

INTRODUC~ON . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 337 Materialsandmethods . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 338 Percentage mortalities due to varying numbers of bacteria.. . . . . . . . . . . . . . . . . . . . . . . . ....

Copyright © 2017 The Korean Association of Internal Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/ by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Korean J Intern Med 2017;32:36...

Mice that lack the adaptor protein DAP12 defy deadly bacterial infections, according to Turnbull and colleagues on page 363. DAP12-deficient mice developed a muted inflammatory response, allowing the immune system to clear the bacteria without triggering septic shock. DAP12 is a transmembrane adaptor protein that is associated with an array of DAP12-deficient mice (dotted line) are resistant to...