BACKGROUND Renal ischaemia-reperfusion (I-R) can cause acute tubular necrosis and chronic renal deterioration. Endoglin, an accessory receptor for Transforming Growth Factor-beta1 (TGF-beta1), is expressed on activated endothelium during macrophage maturation and implicated in the control of fibrosis, angiogenesis and inflammation. METHODS Endoglin expression was monitored over 14 days after ...

BACKGROUND AND PURPOSE Endoglin deficiency causes hereditary hemorrhagic telangiectasia-1 and impairs myocardial repair. Pulmonary arteriovenous malformations in patients with hereditary hemorrhagic telangiectasia-1 are associated with a high incidence of paradoxical embolism in the cerebral circulation and ischemic brain injury. We hypothesized that endoglin deficiency impairs stroke recovery....

BACKGROUND AND PURPOSE A 6-base insertion (6bINS) polymorphism in intron 7 of the endoglin gene (ENG), which codes for a component of the transforming growth factor-beta receptor complex, was reported to be associated with intracranial aneurysm (IA) in a Japanese population. A recent report using a white population could not replicate the association. We tested for this association with high st...

Endoglin is a TGF-beta superfamily receptor critical for endothelial cell function. Mutations in this gene are associated with hereditary hemorrhagic telangiectasia type I (HHT1), and clinical signs of disease are generally more evident later in life. We previously showed that systemic vessels of adult Eng heterozygous (Eng(+/-)) mice exhibit increased vasorelaxation due to uncoupling of endoth...

1Associate Member of ASCE, Ph.D., Assoc. Professor, Dept. of Civil and Env. Eng., Stanford Univ., and Director, Center for Integrated Facility Engineering (Terman Eng. Ctr., 380 Panama Mall, Stanford, CA 94305-4020, USA) E-mail:[email protected] 2Ph.D., Sr. Research Scientist, Dept. of Civil and Env. Eng., Stanford Univ. and Executive Director, Center for Integrated Facility Engineering (CIF...

Electrical Substrate Elimination in 135 Consecutive Patients With Brugada Syndrome Carlo Pappone, MD, PhD; Josep Brugada, MD, PhD; Gabriele Vicedomini, MD; Giuseppe Ciconte, MD; Francesco Manguso, MD, PhD; Massimo Saviano, MD; Raffaele Vitale, MD; Amarild Cuko, MD; Luigi Giannelli, MD; Zarko Calovic, MD; Manuel Conti, MD; Paolo Pozzi, Eng; Andrea Natalizia, PhD, Eng; Simonetta Crisà, Eng; Valer...

Design of a Peripheral Nerve Electrode for Improved Neural Recording of the Cervical Vagus Nerve Bita Sadeghlo Master of Applied Sciences Graduate Department of Electrical & Computer Engineering University of Toronto 2013 Vagus nerve stimulation (VNS) is an approved therapy for patients suffering from refractory epilepsy. While VNS is currently an open loop system, making the system closed loop...

Dept. of Nuclear, Plasma, and Radiological Eng., University of Illinois at Urbana-Champaign, [email protected] Dept. of Nuclear, Plasma, and Radiological Eng., University of Illinois at Urbana-Champaign, [email protected] South Texas Project Nuclear Operating Company, [email protected] South Texas Project Nuclear Operating Company, [email protected] Computational Science and Engineerin...

Click fraud–the deliberate clicking on advertisements with no real interest on the product or service offered–is one of the most daunting problems in online advertising. Building an effective fraud detection method is thus pivotal for online advertising businesses. We organized a Fraud Detection in Mobile Advertising (FDMA) 2012 Competition, opening the opportunity for participants to work on r...

Abstract Heavy rainfall in extreme climates often causes natural disasters such as floods, landslides, and debris flows. Rainfall-induced slope instabilities are major geological (Glade Environ Geol 35:160–174, 1998; Dai et al. Eng 51:279–290, 1999; Iverson Water Resour Res 36:1897–1910, 2000; Lee Pradhan Landslides 4:33–41, 2007; Li 13:1109–1123, 2016a; Ecol 91:477–486, 2016b; Wu Hydro-mechani...