In the phase III DESTINY-Breast04 trial (NCT03734029), T-DXd significantly improved progression-free survival (PFS) and overall (OS) vs TPC in pts with HER2-low mBC regardless of hormone receptor expression. Breast cancers low ER expression (IHC 1-10%) represent a subset that may mimic clinical behavior triple-negative breast cancer. Here, we report analyses IHC 0% 1-10%. Pts (HER2 1+ or 2+/ISH...