Although the biochemical targets of most drugs are known, the biological consequences of their actions are typically less well understood. In this study, we have used two whole-genome technologies in Saccharomyces cerevisiae to determine the cellular impact of the proteasome inhibitor PS-341. By combining population genomics, the screening of a comprehensive panel of bar-coded mutant strains, a...

Templated self-assembly of block copolymers using topographic templates is attractive because it can generate dense nanoscale patterns over a large area with a periodicity down to 10 nm. In our previous work, regular patterns were achieved by using a polystyrene-bpolydimethylsiloxane (PS-b-PDMS) block copolymer and topographic templates . However, more complex block-copolymer patterns required ...

Ressenya a Rafael Roca (Ed.), Ser invisible. Testimonis literaris i documentals femenins, Catarroja-Barcelona, Afers, 2023, 341 pp. ISBN: 978-84-18618-44-4Review to 978-84-18618-44-4

The structure of the C-terminal region of the third cytoplasmic loop (IC3) of the cannabinoid receptor one (CB1) bound to G(alphai1) has been determined using transferred nuclear Overhauser effects (NOEs). The wild-type IC3 sequence is helical when associated with G(alphai1). In contrast, a peptide containing the amino-acid inversion, Ala(341)-Leu(342) adopts a single turn. These findings corre...

Full Text Full Text (PDF) Supporting Online Material Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species Koji Atarashi, Takeshi Tanoue, Tatsuichiro Shima, Akemi Imaoka, Tomomi Kuwahara, Yoshika Momose, Genh Sho Yamasaki, Takashi Saito, Yusuke Ohba, Tadatsugu Taniguchi, Kiyoshi Takeda, Shohei Hori, Ivaylo I. Ivan Kikuji Itoh, and Kenya Honda Science 21 January 2011: 337-341...

*Correspondence: Baskiran Adil, Elazig Road, 15th km, Inonu University School of Medicine, Department of Surgery, Malatya, Turkey 44280 Tel: +90-422-341-06 60-6416 Fax: +90-422-341-0660 E-mail: [email protected] The intra-operative death of a liver transplant recipient is a devastating complication that occurs very infrequently. If the liver graft is exactly procured from the living do...

Multiple myeloma remains incurable despite available therapies, and novel therapies that target both tumor cell and bone marrow microenvironment are urgently needed. Preclinical in vitro and in vivo studies show remarkable anti-multiple myeloma activity of the proteasome inhibitor bortezomib/PS-341 even in multiple myeloma cells refractory to multiple prior therapies, including dexamethasone, m...

In the context of the Burgers equation with distributed controls, we present optimal estimates for the minimal time of controllability T (r) of the initial data of norm r in L2. To cite this article: E. Fernández-Cara, S. Guerrero, C. R. Acad. Sci. Paris, Ser. I 341 (2005).  2005 Académie des sciences. Published by Elsevier SAS. All rights reserved. Résumé Remarques sur la contrôlabilité exact...