Abstract Objectives Because acute myocardial infarction (AMI) may occur suddenly and cannot be predicted, it is critical to identify early diagnosis markers. In recent years, in addition the developing diagnostic methods, other markers that related of AMI are miRNA molecules. The specificity miRNAs involved pathogenesis atherosclerosis regulation cardiac functions has been shown. present study ...

ABSTRACT. The synthesized Zeolite A/ZnCl2 nanoparticles via the hydrothermal route were characterized using FTIR, XRD, and SEM/EDAX techniques. catalyst was used for eco-friendly synthesis of 4,5-dihydro-pyrazole-1-carbothioamide derivatives. Under solvent-free conditions, a multi-component reaction between hydrazine, isothiocyanate, chalcone done with prepared nano-catalyst as an inexpensive, ...

Abstract Multiple myeloma (MM) is a plasma cell malignancy with diverse clinical phenotypes and molecular heterogeneity not completely understood. Differentially expressed genes (DEGs) miRNAs (DEMs) in MM may influence disease pathogenesis, presentation / drug sensitivities. But these signatures overlap meagrely plausibly due to complexity of genome, diversity primary cells studied, technologie...

ABSTRACT O período de transição em vacas leiteiras aumenta o suprimento oxigênio aos tecidos e a produção espécies reativas oxigênio. Junto com comprometimento do sistema antioxidante, gera estresse oxidativo, que pode estar ligado ao desenvolvimento diversas doenças. Este estudo teve como objetivo avaliar oxidativo 35 novilhas Gir, durante periparto. Foram analisados ácido úrico, cobre, ferro,...

Under physiological conditions, cells produce low basal levels of reactive oxygen species (ROS); however, in pathologic conditions ROS production increases dramatically, generating high concentrations toxic unsaturated aldehydes. Aldehyde dehydrogenases (ALDHs) are responsible for detoxification these aldehydes protecting the cell. Due to relevance enzymes, it is important design strategies mod...