The benzo[d]thiazole derivatives 4a–c were synthesized and used for the synthesis of thiophene 6a–f. They form arylhydrazone 8a–i which capable to pyridazine 9a–i 10a–i. latter compounds reacted with thioglycolic acid produce thiazole 12a–i 13a–i, respectively. 15a–c also produced from through their reactions elemental sulfur phenylisothiocyanate. Further heterocyclization 15a carried out deriv...

The title compound, C(15)H(14)N(2)O(3)S(2), is of inter-est with respect to its biological activity. The crystal structure is stabilized by inter-molecular N-H⋯N, C-H⋯O and C-H⋯π hydrogen-bonding inter-actions, as well as offset π-π inter-actions [distance between the centroids of the aryl and thiazole rings of adjacent molecules of 3.954 (2) Å].

a facile and efficient one-pot three-step process for the synthesis of 5-acetyl-2-imino-4-methylthiazoles via the cyclocondensation of 3-thiocyanatoacetylacetone with various hydrazine or hydrazide derivatives in etoh has been developed. 3-thiocyanatoacetylacetone itself has been synthesized as the intermediate from substitution reaction of thiocyanate with 3-chloroacetylacetone. better results...

New acyclovir esters with peptidomimetics were synthesized and evaluated in vitro for their antiviral activity against the replication of Herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2). The influence of peptidomimetics containing oxazole and thiazolyl-thiazole moieties on the antiviral activity is also reported. The esters were synthesized using the coupling reagents N-ethyl-N'-(3-dimet...

Lyngbyabellin M is a non-ribosomal peptide synthetase/polyketide synthase derived metabolite isolated from the cyanobacterium M. bouillonii displaying thiazole rings and a distinct chlorinated octanoic acid chain. Its absolute configuration was proposed based on the comparison of its spectroscopic data with those of other representatives of this family of marine natural products, as well as deg...

Phenylalanine inhibited thiazole biosynthesis in a thiamine-regulatory mutant of Escherichia coli, and the inhibition was overcome by tyrosine.

The combination of thiazole orange and thiazole red as an internal energy transfer-based fluorophore pair in oligonucleotides provides an outstanding analytical tool to follow DNA/RNA hybridization through a distinct fluorescence color change from red to green. Herein, we demonstrate that this concept can be applied to small interfering RNA (siRNA) to monitor RNA integrity in living cells in re...

Activity-guided isolation of the fermentation broth of the deep-sea derived fungus Acaromyces ingoldii FS121, which was obtained from the China South Sea, yielded a new naphtha-[2,3-b]pyrandione analogue, acaromycin A (1) and a new thiazole analogue, acaromyester A (2), as well as the known compound (+)-cryptosporin (3). Their structures, including absolute configurations, were determined by ex...

The thiazorifamycins are derived from rifamycin S and cysteine; rifamycins P and Verde are formed by chemical reactions, while rifamycin Q synthesis involves obligatory enzymatic assistance. All antibiotics come from a common six-member precursor lacking C-1 of cysteine; the thiazin-2-one ring of rifamycin Verde retains both C-2 and C-3 of cysteine, while the thiazole ring of rifamycins P and Q...