miR-221/-222 and components of the urokinase-type plasminogen activator system (uPAS) are associated with metastasis and poor prognosis in breast cancer, including the triple-negative subtype (TNBC). Modification of components of uPAS and involved miRNAs may contribute to targeted therapy for breast cancer patients. miR-221-/-222-overexpressing or miR-221-depleted cells were employed for qRT-PC...

ABSTRACT B3LYP/6-31++G(d) calculations indicated that the reaction of (2E)-3-phenyl-2-nitroprop-2-enenitrile with cyclopentadiene catalyzed by cations of 1,3-dialkylimidazolium ionic liquid shall not take place according to the classical scheme of one-step [2+4] Diels-Alder cycloaddition. Along the path finally leading to bicyclo[2.2.1]hept-5-ene (norbornene) with a nitro group in endo orientat...

Solutions of chloranil (CA) in benzene were irradiated in the presence of Moore's hydrocarbon (MH) and 2-norcarene (NC). These reactions brought about four common products, namely 2,3,5,6-tetrachlorohydroquinone (TCH) and three 1 : 1 cycloadducts, whose C7H10 subunits were reorganised in comparison to the skeletons of MH and NC. As the fifth product, a norcar-3-en-2-yl ether of TCH was formed i...

In this paper electrical conductivity measurements and optical investigations takes place in AOT/ heptane/ (water or aqueous) systems. The water in oil system prepared with adding water in 50% by weight of AOT/ heptane solution.  In other systems instead of water, aqueous solutions of 1) zinc acetate and water 2) Potassium Hydroxide and water were used. In each phase, the trend of the electrica...

The 1:1 reactive intermediates produced in the reaction between alkyl isocyanides and dialkyl acetylenedicarboxylates were trapped with 2-thioxothiazolidin-4-one to generate to highly functionalized ketenimines. A series of new 2-thioxothiazolidin-4-one derivatives were synthesized in moderate yields. The advantages of the present method include good functional group tolerance and simple experi...

Dicer processes microRNAs (miRs) into active forms in a wide variety of tissues, including the liver. To determine the role of Dicer in liver regeneration, we performed a series of in vivo and in vitro studies in a murine 2/3 hepatectomy model. Dicer was downregulated after 2/3 hepatectomy, and loss of Dicer inhibited liver regeneration associated with decreased cyclin A2 and miR-221, as well a...

The method is based on the measurement of color changes in phenol red barbital buffer in heptane-ethanol. It has been applied to human serum and to incubation media containing fatty acids liberated from rat epididymal adipose tissue. The values obtained were found to agree with those using the titrimetric method, within the limit of experimental error. A PROCEDURE FOR the determination of long-...