In dentistry, methylene blue dye (injection USP 1%; American Quinine Co., Inc. Shirley, NY) is mainly used for laboratory research. In endodontics, it is used most often in marginal leakage studies to stain and locate those areas of the root canal system not sealed by the obturating material (1). It is also used to treat methemoglobenemia due to prilocaine toxicity (2, 3). Methyleneblue dye is ...

immobilization of catalysts on the surface of some inert supports makes therecovering step easier. because of the specific physicochemical properties, zeolites are good candidate as catalyst supports. in this study, zeolite x was synthesized by natural kaolin and tio2 was incorporated into zeolite phase by impregnation method. degradation of safranin orange, methylene blue and 2,4–dinitroanilin...

In this study, the indoloquinoline backbone and piperazine were combined to prepare indoloquinoline-piperazine hybrids and their ruthenium- and osmium-arene complexes in an effort to generate novel antitumor agents with improved aqueous solubility. In addition, the position of the metal-binding unit was varied, and the effect of these structural alterations on the aqueous solubility and antipro...

A series of substituted 3-[(substituted-2-chloroquinolin-3-yl)methylene]-5-(substituted-phenyl)-furan-2(3H)-ones (4a-p) have been synthesized and evaluated for their in vitro antimalarial activity against P. falciparum. The title compounds were synthesized by condensing 3-(substituted-benzoyl)propionic acids (3a-d) with substituted 2-chloroquinoline-3-carbaldehydes (2a-d) following modified Per...

compound 3, 3'-methylene-bis-4, 4'-oxycoumarin had remarkable anticoagulant properties. This compound was designated as 'Dicoumarol'. The drug is effective after oral administration in contradistinction to 'Heparin', but takes a longer time to act and its action also persists for a very much longer time than that of 'Heparin'. To increase the absorption rate of 'Dicoumarol' and thereby quicken ...

The controllable synthesis of 3-methylene-2,3-dihydrobenzofurans 2 and 3-methylene-2,3-dihydroindoles 5 has been developed through Rh-catalyzed intramolecular annulation of aromatic rings with azavinyl carbenes.

An efficient and practical procedure for the synthesis of esonarimod, (R,S)-2-acetylthiomethyl-4-(4-methylphenyl)-4-oxobutanoic acid (1), a new antirheumatic drug, has been developed. The intermediate, 2-methylene-4-(4-methylphenyl)-4-oxobutanoic acid (2), was prepared by Friedel-Crafts acylation of toluene with itaconic anhydride (3) in the presence of aluminum trichloride and nitrobenzene in ...

In this work, a combined experimental and theoretical study on molecular structure and vibrational frequencies of (E)-3-(dicyclopropyl methylene)-dihydro-4-[1-(2,5 dimethylfuran-3-yl) ethylidene] furan-2,5-dione [DCPF] were reported. The FT-IR spectra of DCPF isomers are recorded in the solid phase. The equilibrium geometries, harmonic vibrational frequencies, thermo-chemical parameters, total ...

PURPOSE Pericytes are contractile cells outside the endothelial lining of capillaries. The study investigated whether nitric oxide, known to cause relaxation of vascular smooth muscle cells, also relaxes pericytes. METHODS Cultured bovine pericytes were exposed to a nitric oxide donor, sodium nitroprusside, and to 8-bromoguanosine 3':5'-cyclic monophosphate (8-bromo cGMP) in the presence and ...