3,3'-Dicarboxy-4,4'-diaminobiphenyl was synthesized from Onitrobenzoic acid following standard procedures. Diazotization of this compound with isoamylnitrite, under approtic condition gave diphenyl-4,4'-bis-diazonium-3,3'-dicarboxylate and subsequent thermal decomposition of this diazonium compound produced 3,4,3',4'-tetradehydrobiphenyl (bisbenzyne) as a reactive intermediate. Bisbenzyne w...

Severe neurotoxicity due to 5-fluorouracil (FUra) has previously been described in a patient with familial pyrimidinemia. We now report the biochemical basis for both the pyrimidinemia and neurotoxicity in a patient we have recently studied. After administration of a "test" dose of FUra (25 mg/m2, 600 gCi 16-3HJFUra by intravenous bolus) to a patient who had previously developed neurotoxicity a...