Human Bub1 plays an important role at the spindle assembly check-point to prevent cell cycle progression following spindle damage. We examined the expression of Bub1 mRNA and protein in 21 human salivary gland tumors (7 pleomorphic adenomas, 2 warthin tumors, 5 mucoepidermoid carcinomas, 3 adenoid cystic carcinomas and 4 acinic cell carcinomas) and 3 normal submandibular glands using real-time ...

Many settings of unsupervised learning can be viewed as quantization problems | the minimization of the expected quantization error subject to some restrictions. This allows the use of tools such as regularization from the theory of (supervised) risk minimization for unsupervised settings. This setting turns out to be closely related to principal curves, the generative topographic map, and robu...

Acetaminophen is a leading cause of acute liver failure (ALF). Genetic differences might predispose some individuals to develop ALF. In this exploratory study, we evaluated genotype frequency differences among patients enrolled by the ALF Study Group who had developed ALF either intentionally from a singletime-point overdose of acetaminophen (n = 78), unintentionally after chronic high doses of...

PSR B0628-28 is a radio pulsar which was first detected in the X-ray band by ROSAT and then later observed with Chandra and XMM-Newton. The Chan-dra observation yielded an X-ray luminosity two orders of magnitude higher than what is expected for spin-powered pulsars, also there were no pulsations detected. The XMM-Newton observation, however, reveals pulsations at the expected radio period, P =...

One of the greatest challenges we face in the twenty-first century is to sustainably feed nine to ten billion people by 2050 while at the same time reducing environmental impact (e.g. greenhouse gas (GHG) emissions, biodiversity loss, land use change and loss of ecosystem services). To this end, food security must be delivered. According to the United Nations definition, ‘food security exists w...

Infection is one of the major causes of mortality and morbidity in dialysis patients. Dialysis patients appear to be predisposed to infection due to alterations in primary host defence, advanced age and the presence of comorbid conditions, malnutrition and invasive dialysis procedures. Bacteraemia is seldom a manifestation of infection in peritoneal dialysis patients and is usually secondary to...

Calciphylaxis is a rare and devastating obliterative vasculopathy, leading to ischemia and subcutaneous necrosis. In most cases it affects patients with renal disease and is associated with high morbidity and mortality. We present two case reports followed recently in our department, and a literature review on this topic. Case one refers to an 80 -year -old Caucasian woman with chronic kidney d...

International Family Planning Perspectives Young people in South Africa face high levels of unwanted pregnancy and HIV/AIDS. The South African government has cited the high incidence of unwanted pregnancy among youth as one of the major challenges facing the country.1 More than one-third of women nationally have their first child before age 20.2 The overwhelming majority of these pregnancies oc...

This study analysed PCB-contaminated natural soil excavated from an area adjacent to an electrical transformer station in Zadar, Croatia. For one year, PCB concentrations were measured in the soil and leachate water under natural climatic conditions. After 12 months, a negligible quantity of Aroclor 1248 (0.024% in average) and a total of seven key PCB congeners (IUPAC No: PCB-28, PCB-52, PCB-1...