Interleukin-15 (IL-15) is a putative myokine hypothesized to induce an oxidative skeletal muscle phenotype. The specific IL-15 receptor alpha subunit (IL-15Rα) has also been implicated in specifying this contractile phenotype. The purposes of this study were to determine the muscle-specific effects of IL-15Rα functional deficiency on skeletal muscle isometric contractile properties, fatigue cha...

Ileana Acevedo, MD; Abraham Yacoub, MD; John Greene, MD, FACP; Sharoon Quaiser, MD; Raphael Monta; Infectious Disease, University of South Florida College of Medicine, Tampa, FL; H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Moffitt Cancer Center, Tampa, FL; Infectious Disease, Moffitt Cancer Center, Tampa, FL; Medical Student, Infectious Disease, University of South Florida-M...

Verónica A. Segarra*, Michael Birnbaum, Alexandria Ortíz-Rosado, Darlah LópezRodríguez, Victoria Varona, Ji Zha, Shashana Fiedler, Wesam Azaizeh, and Herman Autore Department of Molecular and Cellular Pharmacology, University of Miami, Miami, FL 33136, Department of Acquisitions, University of Miami Richter Library, Coral Gables, FL 33146, Department of Microbiology and Immunology, University o...

Federated learning (FL) has been increasingly considered to preserve data training privacy from eavesdropping attacks in mobile-edge computing-based Internet of Things (EdgeIoT). On the one hand, accuracy FL can be improved by selecting IoT devices with large sets for training, which gives rise a higher energy consumption. other consumption reduced small FL, resulting falling accuracy. In this ...

According to a previously published report, R- and S-flurbiprofen glucuronides were excreted in the bile after iv administration of the pure enantiomers, but only R-flurbiprofen seemed to undergo enterophepatic cycling. To study the possible stereospecificity in the enterohepatic cycling of flurbiprofen (FL), we investigated the pharmacokinetics of R- and S-FL in control and bile-duct cannulate...

Dooshanveer Nuckchady, MD; Michael G. Heckman, MS; Nancy N. Diehl, BS; Darlene Carey, RN; John Moss, MD; Tara Creech, RN; Robert Domnick; Walter C. Hellinger MD; Infectious Disease, Mayo Clinic Jacksonville, Jacksonville, FL; Biostatistics, Mayo Clinic Florida, Jacksonville, FL; Infection Prevention and Control, Mayo Clinic Florida, Jacksonville, FL; Mayo Clinic Florida, Jacksonville, FL; Infor...

OBJECTIVE Pathogenesis in facioscapulohumeral muscular dystrophy (FSHD) appears to be due to aberrant expression, particularly in skeletal muscle nuclei, of the full-length isoform of DUX4 (DUX4-FL). Expression of DUX4-FL is known to alter gene expression and to be cytotoxic, but cell responses to DUX4-FL are not fully understood. Our study was designed to identify cellular mechanisms of pathog...

BACKGROUND DNA integrity analysis could represent an alternative approach to the early detection of colorectal cancer. Previously, fluorescence long DNA (FL-DNA) in stools was extracted using a manual approach and analyzed by capillary electrophoresis assay (CE FL-DNA). We aimed to improve diagnostic accuracy using a simpler and more standardized method [Real Time PCR FL-DNA (RT FL-DNA)] for th...