The interleukin-23 (IL-23) pathway plays a critical role in the pathogenesis of multiple chronic inflammatory disorders, however, inter-individual variability in IL-23-induced signal transduction in circulating human lymphocytes has not been well-defined. In this study, we observed marked, reproducible inter-individual differences in IL-23 responsiveness (measured by STAT3 phosphorylation) in p...

Mutations in the IL23R gene are linked to inflammatory bowel disease susceptibility. Experimental models have shown that interleukin-23 (IL-23) orchestrates innate and T cell-dependent colitis; however, the cell populations it acts on to induce intestinal immune pathology are unknown. Here, using Il23r(-/-) T cells, we demonstrated that T cell reactivity to IL-23 was critical for development of...

IL-23 plays an important role in autoimmune tissue inflammation and induces the generation of not fully characterized effector cells that mediate protection against pathogens. In this paper, we established the essential role of IL-23R in the host response against intracellular pathogens. IL-23 was critical for the expansion or maintenance of gammadelta and double negative (DN) alphabeta T cells...

0009-2614/$ see front matter 2010 Published by doi:10.1016/j.cplett.2010.05.037 * Corresponding author. Address: Department of C fornia, D31 Hildebrand, Berkeley, CA 94720-1460, US E-mail address: [email protected] (R.J. Saykal X-ray absorption spectra of 1 M aqueous solutions of indium(III) chloride, yttrium(III) bromide, lanthanum(III) chloride, tin(IV) chloride and chromium(III) chloride...

Article history: Received 16 January 2008 In final form 15 May 2008 Available online 21 May 2008 0009-2614/$ see front matter 2008 Elsevier B.V. A doi:10.1016/j.cplett.2008.05.045 * Corresponding author. Fax: +972 8 9344123. E-mail address: [email protected] (L Few analytical techniques rival the capabilities of two-dimensional nuclear magnetic resonance. A scheme enabling 2D NMR acq...

0009-2614/$ see front matter 2008 Elsevier B.V. A doi:10.1016/j.cplett.2008.05.060 * Corresponding author. Fax: +1 615 343 7951. E-mail address: [email protected] (C. McCa We present free energy calculations for the Trichoderma reesei Cel7A (cellobiohydrolase I) linker peptide from molecular dynamics simulations directed towards understanding the linker role in cellulose hydrolysis. The c...

0009-2614/$ see front matter 2011 Elsevier B.V. A doi:10.1016/j.cplett.2011.03.027 ⇑ Corresponding author at: Department of Chemist Fort Collins, CO 80523-1872, USA. Fax: +1 970 491 18 E-mail address: [email protected] (E.R. Bern Gas phase monosaccharides (2-deoxyribose, ribose, arabinose, xylose, lyxose, glucose galactose, fructose, and tagatose), generated by laser desorption of solid s...

0009-2614/$ see front matter 2009 Elsevier B.V. A doi:10.1016/j.cplett.2009.11.050 * Corresponding authors. E-mail addresses: [email protected] (A.T. Bel (M. Head-Gordon). The present study describes a new method for obtaining a more accurate transition state estimate through interpolation of the reaction pathway. The method can be implemented using the reaction pathway or during the repara...

The data described are related to the article entitled "Sequence Analysis of Meq oncogene among Indian isolates of Marek׳s Disease Herpesvirus" M. Gupta, D. Deka, Ramneek, 2016. Seven meq genes of Ludhiana Marek׳s disease virus (MDV) field isolates were PCR amplified by using proof reading Platinum Pfx DNA polymerase enzyme, sequenced and then analyzed for the distinct polymorphisms and point m...