Abstract STUDY QUESTION What is the likelihood of success a single cycle preimplantation genetic testing for monogenic disorders (PGT-M), measured as cumulative live birth rate (CLBR) and based on various patient demographics? SUMMARY ANSWER For all women aged ≤40 years, CLBR was at least 10% when number oocytes ≥7 (range 10–30%) or 5% ≥3 5–17%). WHAT IS KNOWN ALREADY The significantly associat...

Introduction Various comorbid conditions can worsen the morbidity and mortality of schizophrenia, this is case for depression, especially through suicidal behaviors cardiometabolic impairments. There a scarcity summarizing data on depressive symptoms disorders among schizophrenia patients living in Africa. Objectives The aim meta-analytic review was to estimate prevalence depression people with...

n engl j med 367;24 nejm.org december 13, 2012 2265 Mississippi . . . .” We’d been told that if the electricity came back on before we hit “ten-Mississippi,” then the backup generators were working fine. A communal sigh was heaved when the count stopped short of double digits. Ventilators and intravenous (IV) pumps hummed on without a hitch. Downstairs, however, water was pouring into the basem...

The objective of this study was to develop the single-well push–pull test as a diagnostic tool for assessing the potential for cation exchange to adversely affect the phase behavior of sodium Ž . dihexyl sulfosuccinate surfactant Aerosol MA 80-I and its solubilization of trichloroethene Ž . TCE in the subsurface. Laboratory push–pull tests were conducted on a model natural aquifer sediment coll...

BACKGROUND The current cost of Xpert MTB RIF (Xpert) consumables is such that algorithms are needed to select which patients to prioritise for testing with Xpert. OBJECTIVE To evaluate two algorithms for prioritisation of Xpert in primary health care settings in a high TB and HIV burden setting. METHOD Consecutive, presumptive TB patients with a cough of any duration were offered either Xpe...

Nephropathic subjects show an increased tendency to develop cardiovascular diseases, mainly as the consequence of several risk factors including increased oxidative stress, inflammation, physical inactivity, anemia, vascular calcification, and endothelial dysfunction. The alterations in lipid metabolism represent a relatively lesser important cause of genesis and progression of atherosclerosis....

ED FROM Shanahan L, Copeland WE, Costello EJ, et al. Child-, adolescentand young adult-onset depressions: differential risk factors in development? Psychol Med 2011;41:2265–74. Correspondence to: L Shanahan, University of North Carolina at Greensboro, Department of Psychology, PO Box 26170, Greensboro, NC 27402, USA; lilly_ [email protected] Sources of funding: National Institute of Mental Heal...

BACKGROUND Microvascular disease is associated with a high risk of macrovascular events in patients with type 2 diabetes, but the impact of macrovascular disease on the risk of microvascular events remains unknown. We sought to evaluate the respective effects of prior microvascular and macrovascular disease on the risk of major outcomes, including microvascular events, in these patients. METH...

During the development of an organism, epithelial tissues provide the basis for major morphogenetic changes. Epithelial cells possess particular characteristics that are essential for their function, such as specialised cell junctions and a distinct apico-basal polarity. Two major types of subapical junctions can be distinguished by electron microscopy in epithelial cells (for recent reviews, s...