www.sciencemag.org (this information is current as of April 13, 2007 ): The following resources related to this article are available online at http://www.sciencemag.org/cgi/content/full/316/5822/222 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/316/5822/222/DC1 can be found ...

www.sciencemag.org (this information is current as of December 2, 2007 ): The following resources related to this article are available online at http://www.sciencemag.org/cgi/content/full/316/5822/222 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/316/5822/222/DC1 can be foun...

www.sciencemag.org (this information is current as of April 13, 2007 ): The following resources related to this article are available online at http://www.sciencemag.org/cgi/content/full/316/5822/222 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/316/5822/222/DC1 can be found ...

Groundwater samples were collected from eight wells in remote Antelope Creek valley, Idaho. Seven out of eight locations showed that groundwater 222 Rn concentrations were much greater than 11 Bq/L (300 pCi/L), a maximum contaminant level (MCL) proposed by United States Environmental Protection Agency (USEPA). Rock and soil samples collected near the sampling wells revealed that 238 U contents ...

PURPOSE The onset of drug resistance is a major cause of treatment failure in multiple myeloma. Although increasing evidence is defining the role of miRNAs in mediating drug resistance, their potential activity as drug-sensitizing agents has not yet been investigated in multiple myeloma. EXPERIMENTAL DESIGN Here we studied the potential utility of miR-221/222 inhibition in sensitizing refract...

MicroRNAs (miRNAs) are short regulatory RNAs that negatively modulate protein expression at a post-transcriptional level. Emerging evidence suggests that miRNAs play important roles in the pathogenesis of several types of cancers. However, the further mechanisms of miRNA remain unknown. In this study, we aimed to explore the coordinated function of miR-221/222 in glioma by bioinformatics and ex...

ducators who understand that schools are complex interdependent social systems can move their organizations forward. Unfortunately, many education leaders today fail to grasp the interconnectedness of these components, resulting in little or no progress. As such, many planned changes address only symptoms, not the underlying root causes, of the problems. Subsequently, meaningful improvements do...

Background: Oxidative stress forms the foundation for the induction of multiple cellular pathways which can lead to the complications of diabetes mellitus that the most debilitating ones are diseases of the nervous system. In this study, we evaluated whether treadmill running could alleviate oxidative stress and apoptosis rate in the hippocampus of streptozotocininduced diabetic rats. Methods: ...

This is an oversimplification, but it will work for this discussion. An animal’s phenotype is observed or measured, but the animal’s breeding value is what is of interest to the sheep breeder. Unfortunately, it is not possible to know the true genetic merit of an animal for a particular trait. Therefore, in order to make selection decisions, its breeding value must be estimated. The animal’s ow...