ABCB1 1673 acceleration 2217 accreditation 850 actinic keratosis 520 active surveillance 2405 activin signalling 2604 acute myeloid leukaemia 783 ADAM9 2945 ADAMs 1535 adaptive design 1950 ADCC 1221 adenocarcinoma 1571, 2688 adherence 831 adhesion 146, 753 adjuvant chemotherapy 313 adjuvant therapy 1133, 1545 adolescent 1342 advanced adenoma 1228 advanced biliary tract cancer 2165 advanced neop...

We report on the identification of a new soft gamma-ray source, IGR J12319–0749, detected with the IBIS imager on board the INTEGRAL satellite. The source, which has an observed 20−100 keV flux of ∼8.3 × 10−12 erg cm−2 s−1, is spatially coincident with an active galactic nucleus (AGN) at redshift z = 3.12. The broad-band continuum, obtained by combining XRT and IBIS data, is flat (Γ = 1.3) with...

BACKGROUND Clinically relevant cutoffs are needed for the interpretation of HIV-1 phenotypic resistance estimates as predicted by "virtual" phenotype HIV resistance analysis. METHODS Using a clinical data set containing 2596 treatment change episodes in 2217 patients in 8 clinical trials and 2 population-based cohorts, drug-specific linear regression models were developed to describe the rela...

0377-2217/$ see front matter 2008 Elsevier B.V. A doi:10.1016/j.ejor.2008.10.030 q This research was supported by NSERC grant (OGP * Corresponding author. Tel.: +1 514 343 5687; fax E-mail addresses: [email protected] umontreal.ca (J.A. Ferland). Most of the real life scheduling problems include several constraints in addition to the precedence and resource constraints considered in t...

The positive results of recent trials for the treatment of acute ischemic stroke have highlighted the importance of imaging selection before endovascular therapy. We performed a stratified meta-analysis to confirm this new understanding. We searched EMBASE, PubMed, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov in April 2015 for randomized controlled trials evaluating th...

Dimethylamine, methylamine, propylamine, and pyrrolidine were the major amines formed by Bacteroides fragilis NCDO 2217 during the active phase of growth in batch culture. Production of these metabolites was strongly pH dependent and was optimal under acidic conditions (pH 6.0). Low pH also favored the formation of pyrrolidine, cadaverine, and dimethylamine by Clostridium perfringens C523, but ...

0377-2217/$ see front matter 2010 Elsevier B.V. A doi:10.1016/j.ejor.2010.03.044 * Corresponding author. Tel.: +1 517 4326439; fax: E-mail address: [email protected] (H. Yildiz). Large automotive supply chains typically involve manufacturers pulling materials from their suppliers along the chain, usually by using round-trip truckload routes. The return trips on these routes are used to return empt...

0377-2217/$ see front matter 2008 Elsevier B.V. A doi:10.1016/j.ejor.2008.03.009 * Tel.: +886 2 26212121. E-mail address: [email protected] Customer complaint problem is a product design used to understand customer requirements. Furthermore, product design corresponding to customer requirement does not feel adequately solved for a cause of problem. The cause of the problem affecting prod...

0377-2217/$ see front matter 2011 Elsevier B.V. A doi:10.1016/j.ejor.2011.12.005 ⇑ Corresponding author. Fax: +55 16 33518240. E-mail addresses: [email protected] (V. (R. Morabito), [email protected] (M. Reiman In real life distribution of goods, relatively long service times may make it difficult to serve all requests during regular working hours. These difficulties are even greater...

We present a mixed-integer programming (MIP) formulation for sensor placement optimization in municipal water distribution systems that includes the temporal characteristics of contamination events and their impacts. Typical network water quality simulations track contaminant concentration and movement over time, computing contaminant concentration time-series for each junction. Given this info...