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19104, 215 898 9633 (f) 215 898 2124, email: [email protected] **Arnold School of Public Health, University of South Carolina, Health Sciences Building, 208B, 800 Sumter Street, Columbia, SC 29208, email: [email protected]. ***Arnold School of Public Health, University of South Carolina, Health Sciences Building, 216B, 800 Sumter Street, Columbia, SC 29208, email: [email protected] Pover...
Aurora kinase A (AURKA) is overexpressed in leukemias. Previously, we demonstrated that AURKA-specific CD8(+) T cells specifically and selectively lysed leukemia cells, indicating that AURKA is an excellent target for immunotherapy. In this study, we examined the feasibility of adoptive therapy using redirected T cells expressing an HLA-A*0201-restricted AURKA(207-215)-specific T-cell receptor ...
Background: Several factors have been implicated in the pathogenesis of colorectal cancer (CRC) associated with ulcerative colitis (UC). We investigated markers of cancer cell pluripotency, including CD44 and CD166, microRNA-21 (miR-21) and microRNA-215 (miR-215), and APC, K-ras and DCC mutations in biopsy specimens from patients with UC to evaluate any correlations with clinical risk factors. ...
Single Hemagglutinin Mutations that Alter Both Antigenicity and Receptor 1 Binding Avidity Influence Influenza Virus Antigenic Clustering 2 Yang Li, David L. Bostick, Colleen B. Sullivan, Jaclyn L. Myers, Sara B. Griesemer, 3 Kirsten St. George, Joshua B. Plotkin, Scott E. Hensley 4 5 Wistar Vaccine Center, Wistar Institute, Philadelphia, PA 19104, USA 6 Department of Microbiology, The Universi...
The immunosuppressive agent cyclosporin A (CsA) also possesses broad-spectrum antimicrobial activity. Previous investigators have reported that the obligate intracellular protozoan Toxoplasma gondii is sensitive to CsA. We have measured the sensitivity of Toxoplasma to 26 CsA derivatives that maintain only a subset of the parent compound's activity. We identified one compound, SDZ 215-918, that...
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