1. Formoterol and salmeterol are the first members of a new generation of long-acting beta(2)-adrenoceptor agonists for inhalation. The discovery of the long effect duration of formoterol was made by chance, while the development of salmeterol appeared to follow a purposeful research strategy. 2. Preclinical evaluation predictive of the clinical duration of effect of long-acting bronchodilators...

A number of different security standards exist and it is difficult to choose the right one for a particular project or to evaluate if the right standard was chosen for a certification. These standards are often long and complex texts, whose reading and understanding takes up a lot of time. We provide a conceptual model for security standards that relies upon existing research and contains conce...

The ISO/IEC 27001 is an important and the most leading international information security management standard in the information security (InfoSec) world. The benefits of implementing the ISO 27001 are to provide market assurance and IT governance, based on customer demands and legal requirements. Although the ISO 27001 is a generic standard for all types of organisations and countries, there a...

Vacuum.-By creating a vacuum the process of decalcification can be characterized as follows: Insoluble calciurn-salts+acid o-soluble calciumsalts+CO2. The carbon dioxide, rapidly extracted, will disturb the balance of the chemical equilibrium, and, according to Le Chatelier, result in an acceleration of the reaction. Waerhaug (1949), however, points out that there will be a more intensive conta...

TheMinkowski sum of two setsA,B ∈ IR, denotedA⊕B, is defined as {a+ b | a ∈ A, b ∈ B}. We describe an efficient and robust implementation for the construction of Minkowski sums of polygons in IR using the convolution of the polygon boundaries. This method allows for faster computation of the sum of non-convex polygons in comparison to the widely-used methods for Minkowski-sum computation that d...

This paper presents a new algorithm for computing the hit point and normal of a ray and a general convex object. The algorithm is loosely based on the the Gilbert-Johnson-Keerthi algorithm for computing the distance between convex objects in the sense that it is applicable to the same family of convex objects and uses the same subalgorithm for computing the closest point of a simplex. Since thi...