BACKGROUND DNA is constantly exposed to reactive oxygen species (ROS), spontaneously arising during the normal oxygen metabolism. ROS may result in temporary as well as permanent modifications in various cellular components such as lipids, proteins and DNA, which may have deleterious consequences. Demonstrating that a dietary supplementation of antioxidants can reduce oxidative DNA damage may p...

Although practice has long been known to improve perceptual performance, the neural basis of this improvement in humans remains unclear. Using fMRI in conjunction with a novel signal detection-based analysis, we show that extensive practice selectively enhances the neural representation of trained orientations in the human visual cortex. Twelve observers practiced discriminating small changes i...

BACKGROUND The immune system in endurance athletes may be at risk for deleterious effects of gasous pollutants such as ambient ozone. Therefore, this study was performed to assess the effect of regular aerobic exercise with ozone exposure on peripheral leukocytes populations in male Wistar rats. METHODS Twenty eight 8 weeks old rats were selected and randomly divided into four groups of ozone...

The purpose of this investigation was to examine the impact of load on the power-, force- and velocity-time curves during the jump squat. The analysis of these curves for the entire movement at a sampling frequency of 200-500 Hz averaged across 18 untrained male subjects is the most novel aspect of this study. Jump squat performance was assessed in a randomized fashion across five different ext...

Three pigeons were trained in a three-item simultaneous same/different task. Three of six stimulus combinations were not trained (untrained set) and were tested later. Following acquisition, the subjects were tested with novel stimuli, the untrained set, training-stimulus inversions, and object shape and color manipulations. There was no novel-stimulus transfer--that is, no abstract-concept lea...

The 1902 Midwives Act introduced training and supervision for midwives in England and Wales, outlawing uncertified-and-untrained midwives (handywomen) and phasing out certified-but-untrained (bona fide) midwives. This paper compares the numbers and practices of these two different types of birth attendant with each other, with qualified and certified midwives and with doctors in early twentieth...

BACKGROUND The aim of this study was to assess validation evidence for a sedation scale for dogs. We hypothesized that the chosen sedation scale would be unreliable when used by different raters and show poor discrimination between sedation protocols. A sedation scale (range 0-21) was used to score 62 dogs scheduled to receive sedation at two veterinary clinics in a prospective trial. Scores re...

Spinal cord injury (SCI) induces incapacitating neuropathic pain in the form of allodynia-a painful response to normally non-noxious stimuli. Unfortunately, the underlying mechanisms of these sensory changes are not well understood, and effective treatments for allodynia have proven elusive. We examined whether physical exercise can improve sensory function after experimental SCI by promoting n...