The sensitivity of A/HeJ, AKR/J, C3H/HeJ, C57BL/6J, C58/J, and DBA/2J male mice to single i.p. injections of 7,12dimethylbenz[a]anthracene (DMBA) was investigated. The drug was administered in a single dose of 0.75 to 3 mg per mouse and animals were sacrificed 5-20 days after injection. The AKR mice were least affected by DMBA. Acute ]>eritoneal inflamma tion accompanied by accumulation of an e...

In this study, it was aimed to investigate the effects of different diets on lipid peroxidation, antioxidants, proliferation and vasculogenesis in liver tissue. BALBC female rats (21) were divided as group fed with standard chow (SC), a ketogenic diet (KD) western (WD). The tap water rat specially prepared according determined for 4 weeks. Liver tissue oxidative damage, evaluated using spectrop...

Background: Rosa damascene constitutes showed different properties like antimicrobial, anti asthma and bronchitis, anti depression, and skin protection. Objective: Survey of effect of rose water extract on male mice reproductive parameter. Methods: In first part of experiment, adult male mice (Balb/c) 25 - 30 gram were divided into three groups; control, 10 and 20 ml/kg/day rose water. Intera...

objective: oximes are important materials in organic chemistry. synparamethyl benzaldehyde oxime (toloaldoxime) is structurally similar to other oximes, hence we have studied its effects on the neonatal and adult female balb/c mice reproductive systems in order to provide a platform for future studies on the production of female contraceptive drugs. materials and methods: in experimental study,...

Introduction: The study aim was to explore a toxicological property and antitumor action of the novel pyridine deriv­ative LHT-17-19 in cell culture on experimental models lung cancer mice.
 Materials methods: performed male female ICR(CD-1), BALB/c, BALB/c nu/nu mice. Pyridine derivative (LHT-17-19) studied as water-soluble pharmaceutical substance. Acute toxicity evaluated groups 5 anima...

Abstract The number of central and peripheral B cells their responsiveness are decreased in aged mice. diversity mice cell repertoires with increasing age has not been elucidated. In this study, we demonstrated that there were significant differences the usage some V , D J genes BCR H-CDR3 repertoire bone marrow cells, spleen memory 3-, 12-, 20-month-old productive, pseudogene, out-of-frame seq...

OBJECTIVE The objective of this article is to investigate the renoprotecive effects of exendin-4 in a mouse model of unilateral ureteral obstruction (UUO) and explore the putative mechanisms. METHODS Male Balbc mice underwent sham operation or UUO surgery, and then received intraperitoneal injection of vehicle or exendin-4, respectively. After 14 days, mice were sacrificed and the left kidney...