CCNE1 is one of the most frequent gene amplifications in high grade serous ovarian cancers (HGSOCs), which occurs in at least 20% of HGSOC and in 30% of established ovarian cancer cell lines. Studies with both primary and metastatic ovary tumor specimens further suggest that the abundance of CCNE1 protein expression correlates with tumor progression and predicts a poor prognosis in ovarian canc...

OBJECTIVE Determination of estrone (E1) levels has a significant meaning in evaluating physiological effect and diagnosing some diseases. In order to detect free E1 in biological fluids, a monoclonal antibody specific for E1 was prepared after the complete antigen of E1 was synthesized. The purified monoclonal antibody was fully characterized for later immunoassay. METHODS 3-O-carboxymethyl e...

Dermal absorption of chlorpyrifos (CPF), an organophosphate (OP) pesticide, is important because of its popular use. Stress has been reported to exacerbate neurotoxic effects of certain OP pesticides; however, quantitative studies to corroborate this are not reported. This study correlates the changes in acetylcholinesterase (AChE) levels and neuronal counts in areas of the hippocampus to conse...

Since two closely related gene isolates of a novel flavivirus, designated hepatitis G virus (HGV) and hepatitis GB virus C (GBV-C), respectively, were first identified (2, 3), 11 HGV/ GBV-C-related gene sequences have been reported. We report here a gene sequence for the envelope 1 (E1) region of an HGV/GBV-C strain obtained from a Japanese patient who had positive titers for HGV, HCV, and HBV....

Tumour necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK), a member of the TNF family, is a multifunctional cytokine that regulates cell growth, migration, and survival principally through a TWEAK receptor, fibroblast growth factor-inducible 14 (Fn14). However, its physiological roles in bone are largely unknown. We herein report various effects of TWEAK on mouse osteoblastic MC3T3-E1...

In 1965 Hayashida and Nishi initiated the study of genus 2 curves C whose Jacobian JC is isomorphic to a product A = E1×E2 of two elliptic curves. In their papers [12], [14] and [13], they determined the number of curves C with JC ' A for a fixed A in many cases, thereby exhibiting the existence of such curves. A similar count was done for supersingular curves by Ibukiyama, Katsura and Oort[16]...

BACKGROUND Aedes aegypti and Aedes albopictus are potential vectors of chikungunya virus (CHIKV). The recent CHIKV outbreaks were caused by a new variant characterized by a mutation in the E1 glycoprotein gene (E1-226V) which has favored a better transmissibility by Ae. albopictus. As Ae. albopictus tends to replace Ae. aegypti in many regions, one question remained: is Ae. albopictus as effici...

Endoglucanase E1 from Acidothermus cellulolyticus was expressed cytosolically under control of the cauliflower mosaic virus 35S promoter in transgenic duckweed, Lemna minor 8627 without any obvious observable phenotypic effects on morphology or rate of growth. The recombinant enzyme co-migrated with the purified catalytic domain fraction of the native E1 protein on western blot analysis, reveal...

Let X be a smooth projective curve of genus g ≥ 2 over the complex numbers. A holomorphic triple (E1, E2, φ) on X consists of two holomorphic vector bundles E1 and E2 over X and a holomorphic map φ : E2 → E1. There is a concept of stability for triples which depends on a real parameter σ. In this paper, we determine the Hodge polynomials of the moduli spaces of σ-stable triples with rk(E1) = 3,...

The pyruvate dehydrogenase (E1) and acetyltransferase (E2) components of pig heart and ox kidney pyruvate dehydrogenase (PDH) complex were separated and purified. The E1 component was phosphorylated (alpha-chain) and inactivated by MgATP. Phosphorylation was mainly confined to site 1. Addition of E2 accelerated phosphorylation of all three sites in E1 alpha and inactivation of E1. On the basis ...