Cloretazine (VNP40101M; 101M; 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(methylamino)carbonyl]hydrazine) is a sulfonylhydrazine prodrug that generates both chloroethylating and carbamoylating species on activation. To explore the molecular mechanisms underlying the broad anticancer activity observed in preclinical studies, cloretazine and chloroethylating-only [i.e., 1,2-bis(methylsulfonyl)-...

2-Chloroethyl ethyl sulfide (CEES) is used as a simulant for mustard (HD) in a study to develop secondary ion mass spectrometry (SIMS) for rapid, semi-quantitative detection of mustard on soil. Using SIMS with single-stage mass spectrometry, a signature for CEES can be unequivocally observed only at the highest concentrations (0.1 monolayer and above). Selectivity and sensitivity C2H5SC2Hl from...

Investigations of pharmacodynamic parameters (postantibiotic effect [PAE], sub-MIC effects [SMEs], etc.) have been progressively employed for the design of dosing schedules of antimicrobial agents. However, there are fewer in vivo than in vitro data, probably because of the simplicity of the in vitro procedures. In this study, we have investigated the in vitro PAE, SME, and previously treated (...

O-Cholesteryl-O-phenyl-N-phenylphosphoramidate (1) and four organotin (lV) derivatives of the ambidentate O-cholesteryl-O -phenyl phosphorothioate ligand formulated as Me(3) SnOSPR'R"(2), Ph(3)SnOSPR'R"(3), O(CH(2)CH(2)S)(2)Sn(n-Bu)OSPR'R"(4), S(CH(2)CH(2)S)(2)Sn(n-Bu)OSPR'R"(5), (R' = O-phenyl; R"= O-cholesteryl) were subjected to cytotoxicity screening against KB (nasopharingel carcinoma), OV...

Reaction with thiol converts the antitumor natural product leinamycin to an episulfonium ion that alkylates the N(7)-position of guanine residues in double-stranded DNA. The sequence specificity for DNA alkylation by this structurally novel compound has not previously been examined. It is reported here that leinamycin shows significant (>10-fold) preferences for alkylation at the 5'-G in 5'-GG ...

The pollution status and characteristics of PAEs (phthalate esters) were investigated in indoor air of offices, and PAEs of both gas-phase and particulate-phase were detected in all the samples. The concentration (sum of the gas phase and the particulate phase) was 4748.24 ng/m3, ranging between 3070.09 and 6700.14 ng/m3. Diethyl phthalate, dibutyl phthalate, and di(2-ethylhexyl) phthalate were...

Correspondence to: Edson Hilgert Rua Francisco Paes, 31, apto. 22 Centro São José dos Campos CEP 12210-100 São Paulo Brazil Phone: +055 012 39227621 E-mail:[email protected] Abstract This study evaluates the marginal adaptation of ceramic copings front of two finish lines and addition of ceramic. Hence, two master steel dies were milled with all-ceramic crowns preparation, one with a round sho...

The influence of half-life on the postantibiotic effect (PAE) of tobramycin against Pseudomonas aeruginosa and Staphylococcus aureus was investigated during one dosing interval. Tobramycin half-lives of 0.5 to 2.5 h were simulated in an in vitro model, and the PAE was determined by an enzymatic inactivation method at different time points, i.e., when the tobramycin concentrations were 20x, 5x, ...