The goal of this study was to provide a reasonable assessment of how probe substrate selection may impact the results of in vitro aldehyde oxidase (AO) inhibition experiments. Here, we used a previously studied set of seven known AO inhibitors to probe the inhibition profile of a pharmacologically relevant substrate N-[(2dimethylamino)ethyl]acridine-4-carboxamide (DACA). DACA oxidation in human...

The goal of this study was to provide a reasonable assessment of how probe substrate selection may impact the results of in vitro aldehyde oxidase (AO) inhibition experiments. Here, we used a previously studied set of seven known AO inhibitors to probe the inhibition profile of a pharmacologically relevant substrate N-[(2dimethylamino)ethyl]acridine-4-carboxamide (DACA). DACA oxidation in human...

The activities of aldehyde oxidase and xanthine oxidase were determined in partially purified preparations from livers and kidneys of male and female Dhubb, Uromastyx microlepis, four times daily at equal intervals. The maximum activity of male and female hepatic aldehyde oxidase appeared at 2100 h, whereas the minimum activity was observed at 0300 h, using phthalazine and 3-methylisoquinoline ...