The indolyl -NH group of the title Schiff base, C(19)H(19)N(3)O(2), forms a hydrogen bond to the -OH group of an inversion-related mol-ecule, resulting in a hydrogen-bonded dimer; adjacent dimers are further linked through an inter-dimer N-H⋯O hydrogen bond involving the -C(=O)-NH-N=fragment to form a linear ribbon that runs along the a axis.

The reaction of indole derivatives with cyanoacetic acid followed by treatment with DMFDMA gave the intermediate indolyl enaminonitriles (3). Further reaction with aminoguanidine yielded 5 ́-cyanomeridianin analogues (4). The same intermediate reacted with pmethoxyphenylhydrazine to give the pyrazolyl derivative (8). Treatment of (2E)-3-dimethylamino-2-(1H-indol-3-yl)-propenoate (3a) with hydrox...

β-Cyclodextrin sulfuric acid as a green Lewis acid catalyst has been applied for the preparation of bis(indolyl)methanes, tris(indolyl)methanes and 3,3'-diindolyloxindole derivatives by the condensation of indoles with various carbonyl compounds in aqueous media with high to excellent yields.

In this work, a green, simple and highly efficient procedure for the synthesis of bis(indolyl)methanes is described. The condensation of indoles with carbonyl compounds catalyzed by citric acid in water affords bis(indolyl)methanes in high yields and relatively short reaction times. The advantages of this method are using of water as a low cost solvent and efficient recyclability of the catalyst.

background: phthalate esters have been shown to cause reproductive toxicity in both developing and adult animals. objective: this study was designed to assess long-term effects of maternal exposure to di (2-ethylhexyl) phthalate (dehp) on reproductive ability of both neonatal and adult male offspring. materials and methods: 60 female rats randomly divided in four equal groups; vehicle control a...