To continue our systematic SAR studies a series of N-phenylamino derivatives of 2-azaspiro[4.4]nonane-, 2-azaspiro[4.5]decane-, 6-methyl-2-azaspiro[4.5]decane-1,3-dione and 3-cyclohexylpyrrolidine-2,5-dione were synthesized and tested for their anticonvulsant activity in the maximum electroshock seizure (MES) and subcutaneous metrazole seizure threshold (sc. Met) tests. Among those molecules th...

Chem. Abstr. Serv. Reg. No.: 126-07-8 Deleted CAS Nos: 8027-03-0; 8055-10-5; 3426-54-8; 11103-62-1; 24659-79-8 Chem. Abstr. Name: (1′S,6′R)-7-Chloro-2′,4,6-trimethoxy-6′-methylspiro[benzofuran-2(3H),1′-[2]cyclohexene]-3,4′-dione IUPAC Systematic Name: 7-Chloro-2′,4,6-trimethoxy-6′β-methylspiro[benzofuran-2(3H),1′-[2]cyclohexene]-3,4′-dione Synonyms: (2S,4′R)-7-Chloro-2′,4,6-trimethoxy-4′-methyl...

The heterocycle in the title compound {systematic name: (5S)-5-[(1S)-1-methyl-prop-yl]pyrrolidine-2,4-dione}, C(8)H(13)NO(2), is planar (r.m.s. deviation for all non-H atoms = 0.008 Å). The crystal structure is stabilized by N-H⋯O hydrogen bonding.

The title disubstituted naphthalene-1,4-dione, C(24)H(16)Cl(2)O(2), has the two chloro-benzyl substituents related by a non-crystallographic twofold rotation axis, generating a chiral conformation; both enantiomers are present. The two chlorobenzene rings are nearly perpendicular to the fused ring system, making angles of 88.8 (1) and 77.5 (1)° with it.

In the title compound, C(11)H(9)Cl(2)NO(2), the dihedral anngle between the mean planes of the aromatic ring and the twisted pyrrolidinedione ring is 79.98 (9)°.

The title mol-ecule, C9H7NO3, exists in the diketo form and the iso-quinoline unit is approximately planar (r.m.s. deviation = 0.0158 Å). In the crystal, mol-ecules are linked into inversion dimers through pairs of O-H⋯O hydrogen bonds and are further assembled into the (100) layers via stacking inter-actions [centroid-centroid distances = 3.460 (3) and 3.635 (4) Å].