tion mechanism from existing antifungal agents, and its clinical efficacy is expected. MCFG exhibits a wide antifungal spectrum against Candida and Apergillus species in vitro by inhibiting biosynthesis of the major fungal cell wall component, 1,3-b-D-glucan. Its superior transfer to the lung may be highly effective for prevention and treatment of pulmonary mycosis. Clinically, MCFG is particul...

Founder and first director of the Montreal Neurological Institute, Wilder G. Penfield established the "Montreal Procedure" for the surgical treatment of epilepsy, a brain disorder characterized by sudden and recurrent seizures. His revolutionary work is the very foundation of neurological studies. He was celebrated as 'the greatest living Canadian.'

This is the first publication of any genus Metarbelidae Strand, 1909 for Madagascar since 1891. Here, Saalmulleria Mabille, 1891 revised comprising three species including descriptions two new species. Three genera are presented: first, an African-Madagascan sister genus-group, namely Shimbania gen. nov. and Morondavania The monotypic comprises one species, while 13 which 11 to science. Lebedod...

Although the colon shows, with all other tissues of the body, a liability to invasion by both miliary and caseous tubercle, it has also a peculiar form of reaction, so unlike ordinary tuberculous manifestations that it has until recently been confounded with ?carcinoma. In 1891, however, Hartmann, in France, and Billroth, at Vienna, drew attention to the occurrence of large, hard,

www.sciencemag.org SCIENCE VOL 326 9 OCTOBER 2009 193 COVER First described by David Hilbert in 1891, the Hilbert curve is a one-dimensional fractal trajectory that densely fills higher-dimensional space without crossing itself. A new method for reconstructing the three-dimensional architecture of the human genome, described on page 289, reveals a polymer analog of Hilbert’s curve at the megaba...

A revision of the Alticini genera from the Afrotropical region is reported. The paper includes the following for the flea beetle fauna occurring in Sub-Saharan Africa and Madagascar: a key to their identification; habitus photos of all the genera; microscope and scanning electron micrographs of many diagnostic morphological characters; and an updated annotated catalogue with biogeographical not...