We have analyzed a cloned #{176}-thalassemia ($#{176}-thal) gene from a patient doubly heterozygous for hemoglobin Lepore and $#{176}-thalassemia. Studies of 3H-uridine incorporation into 9-globin mRNA in this patient’s erythroblasts suggested an intranuclear defect in both $ and Lepore (#{246} ) mRNA synthesis, as did S nuclease analysis of nuclear RNA. However, the nucleotide sequence of the ...

We investigated the stability of certain erythrocytic enzymes as assayed qualitatively by fluorescence spot tests. Preservation of the activities of glucose6-phosphate dehydrogenase (GPD), pyruvate kinase (PK), triose phosphate isomerase (TPI), glutathione reductase (GTD), and NADH diaphorase (ND) in heparin, glucose-EDTA, or Alsever’s solution was studied at -20#{176}C and 30#{176}C. In Alseve...

Outbreaks due to Clostridium difficile polymerase chain reaction (PCR) ribotype 027, toxinotype III, were detected in 7 hospitals in the Netherlands from April 2005 to February 2006. One hospital experienced at the same time a second outbreak due to a toxin A-negative C. difficile PCR ribotype 017 toxinotype VIII strain. The outbreaks are difficult to control.

The mammalian target of rapamycin (mTOR) and phosphoinositide-3-kinase (PI3K) pathways are often aberrantly activated in acute myeloid leukemia (AML) and play critical roles in proliferation and survival of leukemia cells. We provide evidence that simultaneous targeting of mTOR complexes with the catalytic mTOR inhibitor OSI-027 and of the p110α subunit of PI3K with the specific inhibitor BYL-7...

6.11 Buoyancy and Its Regulation ....................................... 176 6.11.1 Gas Vacuole Structure ..................................................... 176 6.11.2 Pressures Acting on Gas Vesicles .................................... 176 6.11.3 Buoyancy Regulation ...................................................... 177 6.11.4 Sinking or Floating ..........................................

We have analyzed a cloned #{176}-thalassemia ($#{176}-thal) gene from a patient doubly heterozygous for hemoglobin Lepore and $#{176}-thalassemia. Studies of 3H-uridine incorporation into 9-globin mRNA in this patient’s erythroblasts suggested an intranuclear defect in both $ and Lepore (#{246} ) mRNA synthesis, as did S nuclease analysis of nuclear RNA. However, the nucleotide sequence of the ...

Five age groups (CA 7-9, 10-12, 13-16,120-21,^027) of Ss were selected from two contrasting populations in Urban and Rural Yucatan, Mexico. All Urban Ss were in school, while only the two younger Rural age groups were in school--older Rural Ss had little or no schooling. The Ss were tested on a short-term and inciden-

Cui Tang 1,2,* ID , Xianggen Yin 1,2 and Zhe Zhang 1,2 1 State Key Laboratory of Advanced Electromagnetic Engineering and Technology, Huazhong University of Science and Technology, Wuhan 430074, China; [email protected] (X.Y.); [email protected] (Z.Z.) 2 Electric Power Security and High Efficiency Laboratory, Huazhong University of Science and Technology, Wuhan 430074, China * Correspondence:...

Elimination of Clostridium difficile spores from the clinical setting requires stringent application of infection control procedures including the use of hard-surface disinfectants. A unique combination of sodium taurocholate together with amino acids has been reported as an alternative approach to potentially eliminating spores of C. difficile by increasing their sensitivity to common disinfec...