Colorectal cancer is one of the major public health issues worldwide due to its high mortality and morbidity. Angiogenesis fundamental step tumors transition from dormant malignant state it recognized as hallmarks cancer. High mobility group AT-hook 2 encodes a small non-histone chromatinassociated protein that can modulate transcription by altering chromatin architecture. Currently mechanism w...

Ovarian cancer is the eighth most common cancer in women worldwide, and epithelial ovarian cancer (EOC) represents 90% of cases. Nerve growth factor (NGF) and its high affinity receptor tyrosine kinase A receptor (TRKA) have been associated with the development of several types of cancer, including EOC; both NGF and TRKA levels are elevated in this pathology. EOC presents high angiogenesis and ...

Modulating angiogenesis is an attractive goal because many pathological conditions depend on the growth of new vessels. Angiogenesis is mainly regulated by the VEGF, a mitogen specific for endothelial cells. In the last years, many efforts have been pursued to modulate the angiogenic response targeting VEGF and its receptors. Based on the x-ray structure of VEGF bound to the receptor, we design...

BACKGROUND The beneficial effect of Δ-17 FAD is poorly understood. The aim of this study was to investigate the protective mechanism of fatty acids against atherosclerotic (AS) damage induced by oxidized low-density lipoprotein (ox-LDL) in human umbilical vein endothelial cells (HUVECs), and to identify the molecular mechanisms involved. MATERIAL AND METHODS The ox-LDL was used to induce lipoto...

Introduction Systemic sclerosis (SSc) is a chronic, autoimmune connective tissue disease characterized by immune system activation, vasculopathy, and collagen accumulation. Despite progressive fibrosis of the vasculature, compensatory angiogenesis impaired. The cause shift towards anti-angiogenesis observed in SSc unknown. IL-17 cytokine family participates pathogenesis angiogenesis. Material m...

Early angiogenesis is a key step in the transition from acute to persistent inflammation. The nervous system has long been known to play a role in inflammation, in part through the release of substance P from peripheral nerve terminals (neurogenic inflammation). Application of substance P can stimulate vessel growth in a variety of angiogenesis assays, although it was previously not known wheth...

Different mechanisms such as cell migration, proliferation, branching, anastomosis, and lumen formation occur during the angiogenesis process. Lumen formation is one of the critical mechanisms which is not only necessary for the functional plexus but also for continuing of angiogenesis process. Although multiple studies investigated this mechanism during the angiogenesis process in both in vivo...

Angiogenesis is defined as the sprouting of new capillaries from pre-existing ones. Angiogenesis is a prerequisite for growth and differentiation of organs and tissues and is involved in many pathological processes, for example growth and metastasis of tumours. Numerous in vivo and in vitro models of angiogenesis have been developed in order to identify and analyse pro- and antiangiogenic facto...

Interleukin-17 (IL-17) is a CD4 T-cell– derived proinflammatory cytokine. We investigated the effects of locally produced IL-17 by tumors as a means to evaluate its biologic function. Although recombinant IL-17 protein or retroviral transduction of IL-17 gene into tumors did not affect in vitro proliferation, IL-17 transfectants grew more rapidly in vivo when compared with controls. Immunostain...