BACKGROUND Optimisation of atrioventricular (AV) delay time has positive effects on left ventricular (LV) functions in patients with a DDD pacemaker. However, the method used for optimisation is still debated. AIM To evaluate the effect of different AV delay times on various LV systolic performances by using automated functional imaging (AFI) in patients with a DDD pacemaker and preserved LV ...

A series of para-substituted phenolic N-alkyl carbamates were evaluated for their FAAH and MGL inhibitory activities. The compounds were generally selective for FAAH, with IC(50) values in the nM range, whereas inhibition of MGL required concentrations three orders of magnitude higher. The most potent compounds, dodecylcarbamic acid 4-(4,5-dihydrothiazol-2-yl)phenyl (12) and 4-(1,2,3-thiadiazol...

A study was conducted to evaluate the correlation between selected physico-chemical parameters of water and their effects on growth of Rainbow trout (Oncorhynchus mykiss) in raceway system in the area of Sarab Gerdu, Iran. The samples were collected from twenty raceways (270- day old fish, surface area 55m2 flow rate 150 ls-1 total production 15 T). Physico-chemical parameters were the fluctuat...

In Nepal, blanket fertilizer recommendations without considering diverse soil types, nutrient status, climate and crop management practices along with imbalanced fertilization by farmers, mainly “urea fertilizer,” have resulted in reduced nitrogen use efficiency (NUE) productivity tomato production. Optimizing the rate of (N) fertilizer, application time improved methods could increase yields N...

−Biodegradation of methylene chloride by a mixed microbial culture, isolated from a common sewage treatment plant, was investigated in a batch system. Batch experiments were performed at room temperature (27 C) and pH value of 7. The methylene chloride concentration in growth media varied from 25 mgl to 250 mgl. A maximum observed degradation was 1 mglh at 100 mgl of methylene chloride. The cul...

Abstract Macrophage plasticity and functional activation are critical to the broad array of macrophage-mediated functions that help determine disease outcomes. galactose-type lectin (MGL), a type-2 C-type receptor (CLR) primarily expressed on myeloid cells, has been shown play an anti-inflammatory role in innate response some infectious agents. Our lab recently demonstrated MGL-1 contributes an...

Although sialic acid has long been recognized as the primary receptor determinant for attachment of influenza virus to host cells, the specific receptor molecules that mediate viral entry are not known for any cell type. For the infection of murine macrophages by influenza virus, our earlier study indicated involvement of a C-type lectin, the macrophage mannose receptor (MMR), in this process. ...

The body maintains Mg(2+) homeostasis by renal and intestinal (re)absorption. However, the molecular mechanisms that mediate transepithelial Mg(2+) transport are largely unknown. Transient receptor potential melastatin 6 (TRPM6) was recently identified and shown to function in active epithelial Mg(2+) transport in intestine and kidney. To define the relationship between Mg(2+) status and TRPM6 ...

The endogenous cannabinoids anandamide (N-arachidonoylethanolamide, AEA) and 2-arachidonoyl glycerol (2-AG) are upregulated during liver fibrogenesis and selectively induce cell death in hepatic stellate cells (HSCs), the major fibrogenic cells in the liver, but not in hepatocytes. In contrast to HSCs, hepatocytes highly express the AEA-degrading enzyme fatty acid amide hydrolase (FAAH) that pr...