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BACKGROUND Angiogenesis is pivotal in tumor development. Vascular endothelial growth factor-A (VEGF-A) is considered one of the most important angiogenic factors, but lately several microRNAs (miRs) have been associated with vascular development. miR-126 has been related to tumor angiogenesis and in the regulation of VEGF-A. The authors aimed to investigate the prognostic impact of miR-126 and ...
رمان بهای عشق شامل 11 داستان کوتاه می باشد که در اینجا ما فقط به ترجمه چهار داستان پرداخته ایم. داستان های این مجموعه تغییرات خلق و خو، تخیل و خیال پردازینویسنده ای را منعکس می سازند که فی البداهه نقش شاهدی سرگرم یا متاثر را بازی می کند، یعنی بازیگری که برای بهتر پنهان کردن خود از ضمیر " من" استفاده می کند، کاراگاه یا حتی مورخ زیباترین حکایت ها و اساطیر یونانی.
Ping-Ping Lv ([email protected]) Ye Meng ([email protected]) Min Lv ([email protected]) Chun Feng ([email protected]) Liu Ye ([email protected]) Jing-Yi Li ([email protected]) Dan-Qin Yu ([email protected]) Yan Shen ([email protected]) Xiao-Lin Hu ([email protected]) Qian Gao ([email protected]) Shan Dong ([email protected]) Xian-Hua Lin ([email protected]) Gu-Feng Xu (xu...
Fengxi Su Prof ([email protected]) Ran Gu Dr ([email protected]) Weijuan Jia M.D. ([email protected]) Yunjie Zeng Dr ([email protected]) Nanyan Rao Prof ([email protected]) Yue Hu Dr ([email protected]) Shunrong Li Dr ([email protected]) Jiannan Wu Dr ([email protected]) Liang Jin Dr ([email protected]) Lijuan Chen ([email protected]) Erwei Song Prof ([email protected]) Meijun Long Dr ...
The toxic actions of scrapie prion protein (PrP(sc)) are poorly understood. We investigated the ability of the toxic PrP(sc) fragment 106-126 to interfere with evoked catecholamine secretion from PC-12 cells. Prion protein fragment 106-126 (PrP106-126) caused a time- and concentration-dependent augmentation of exocytosis due to the emergence of a Ca(2+) influx pathway resistant to Cd(2+) but se...
Background. The purpose of the present study was to assess the feasibility of using miR-126 in the urine as a biomarker for diabetic nephropathy. Methods. miRNAs were extracted from the urine samples of T2DM patients with diabetic nephropathy (DN; n = 92), T2DM without DN (n = 86), and 85 healthy volunteers using quantitative reverse transcriptase polymerase chain reaction (real-time polymerase...
Recent evidence showed that limited activation of PI3K/Akt pathway was critical for induction and function sustainment of CD4(+) Foxp3(+) regulatory T cells (Tregs). However, the underlying mechanism remains largely unknown. In this study, we reported that miR-126 was expressed in mouse and human Tregs. Further study showed that silencing of miR-126 using miR-126 antisense oligonucleotides (ASO...
Lineage specification is thought to be largely regulated at the level of transcription, where lineage-specific transcription factors drive specific cell fates. MicroRNAs (miR), vital to many cell functions, act posttranscriptionally to decrease the expression of target mRNAs. MLL-AF4 acute lymphocytic leukemia exhibits both myeloid and B-cell surface markers, suggesting that the transformed cel...
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