Recent advances in optical technology have taken fluorescent imaging beyond the standard two-dimensional (2D) epifluorescence imaging into the realm of three-dimensional (3D) fluorescence molecular tomographic (FMT®) imaging for improved localization and quantification in deep tissue. This requires the transillumination of animals (i.e. the passing of light through the animals) rather than the ...

ABSTRACT Desorption electrospray ionization-mass spectrometry imaging (DESI-MSI) is a powerful tool to analyze the distribution of metabolites in biological tissues. Cryosectioning tissues usually required prior DESI-MSI, but it can be difficult for that are fragile, hard, and have high-water content. The Kawamoto method uses transparent adhesive films prepare cryosections; however, its applica...

BACKGROUND Positron emission tomography (PET) is poised to become a useful imaging modality in staging and evaluating therapeutic responses in patients with metastatic pancreatic cancer (mPC). This analysis from a phase 1/2 study examined the utility of early PET imaging in patients with mPC treated with nab-paclitaxel plus gemcitabine. METHODS Tumors were measured by [18F]2-fluoro-2-deoxyglu...

Background: To date, several imaging techniques to track stem cells are used such as positron emission tomography (PET), single photon emission computed tomography (SPECT), Bioluminescence imaging (BLI), fluorescence imaging, CT scan and magnetic resonance imaging (MRI). Although, overall sensitivity of MRI compared to SPECT and Bioluminescence techniques are lower, but due to high spatial reso...

Plant genetic transformation requires appropriate choice of antibiotics for regeneration of transformed tissues and elimination of Agrobacterium, and minimal concentration of selective agents for the selection of putative transformants during transformation. This study was conducted to examine the effects of three antibiotics (carbenicillin, cefotaxime, and Clavamox) on in vitro plant regenerat...

BACKGROUND Thyroxine (T4) hormone is synthesized by the thyroid gland and then released into the systemic circulation where it binds to a number of proteins. Dysfunction in T4 transport mechanisms has been demonstrated in multiple central nervous system (CNS) diseases including Alzheimer's disease. In the presence of different compounds that inhibit potential T4 transport mechanisms, this study...

In the last few decades, a number of radiopharmaceuticals for imaging inflammation have been proposed that differ in their specificity and mechanism of uptake in inflamed foci as compared to the traditional inflammation imaging agents. Radiolabelled cytokines represent a reliable tool for the preclinical diagnosis of chronic inflammatory processes, even before anatomical and functional changes ...

Here, we report a method for high-sensitivity fluorescence imaging of iron, which demonstrates the abundance and distribution of iron in plant tissues more precisely than conventional histochemical staining procedures. The fluorescence turn-on method is rapid (<20 min), inexpensive to set up, and expected to be readily applicable to any plant tissues.

We are delighted to write these editorials on what has been a very exciting project involving world leading experts on the development of sensors and imaging agents for these two themed issues on sensor targets and imaging agents. Through the coordination and editing of these two issues we were able to take advantage of each other’s extensive knowledge in the areas of sensing and imaging. The c...

Near-infrared (NIR) fluorescence imaging agents are promising tools for noninvasive cancer imaging. This study explored the specific uptake and retention of a NIR heptamethine carbocyanine MHI-148 dye by canine cancer cells and tissues and human prostate cancer (PCa) specimens and also the dye uptake mechanisms. The accumulation of MHI-148 was detected specifically in canine cancer cells and ti...