There has been increasing interest in recent years in the prevalence of low 25-hydroxy (OH) vitamin D concentrations in different human populations [1, 2]. There are 2 forms of vitamin D: cholecalciferol (vitamin D3) and ergocalciferol (vitamin D2). Vitamin D3 is manufactured through the photoisomerization of 7-dehydrocholesterol to pre-vitamin D3, which then undergoes a temperature-dependent r...

Vitamin D1 Compound of ergocalciferol with lumisterol (stereoisomer of ergosterol) 1:1 ratio Vitamin D2 Ergocalciferol (made from ergosterol) Vitamin D3 Cholecalciferol (made from 7dehydrocholesterol in the skin) Vitamin D4 22-dihydroergocalciferol Vitamin D5 Sitocalciferol (made from 7-dehydrositosterol) Vitamin D6 Calciferol 25-(OH) Vitamin D Calcidiol or calcifediol; indicates no distinction...

Waterhouse et al. criticized the association between vitamin D intake and the prevention of pancreatic cancer (1), an association that has been thoroughly reviewed in recent years (2, 3). Yet, randomized controlled clinical trials (RCTs) very rarely produced encouraging and reliable results on the field (4–7). Negative evidence in animal models and experimental studies (8, 9) should suggest tha...

background: dendritic cells (dcs) play a central role in the initiation and expansion of t cell mediated immune responses with potential immunotherapy application. the compounds which have the ability to induce immunomodulatory effects on dcs may be employed for the treatment of immunopathologic conditions such as autoimmune diseases. objective: the aim of this study was to investigate the in v...

The present study was undertaken to investigate the toxic effects of higher doses (1,00,000 IU i.e. 2.5 mg/kg body weight (BW)) of vitamin D3, concomitantly with bacterial endotoxins (lipopolysaccharides: LPS) to study the immunomodulatory potential of vitamin D3 in IBL-80 broiler chicks. The chicks were divided into four groups [group I (NSS), group II (LPS), group III (Vit. D3 + NSS), and gro...

BACKGROUND We conducted a single-arm clinical trial in institutionalized seniors, on the effects of high-dose vitamin D3-fortified bread daily intake (clinicaltrials.gov registration NCT00789503). METHODS At 1 and 3 years after the dietary fortification was stopped, serum 25-hydroxyvitamin D (25(OH)D), parathyroid hormone (PTH) and bone mineral density were measured in 23 of the original stud...

Vitamin D3 is an important vitamin in vertebrates. This fat-soluble vitamin is associated with the regulation of many physiologic processes, most importantly calcium metabolism. The presence or importance of vitamin D3 has been determined in only a handful of invertebrate species. In this study, hemolymph was collected from six wild-caught, subadult goliath birdeater spiders (Theraphosa blondi)...

25-Hydroxy-24-oxovitamin D3 (25(OH)24-oxo-D3), a metabolite of 25-hydroxyvitamin D3, has been chemically synthesized. The ultraviolet, mass, infrared, and proton nuclear magnetic resonance spectra of the 25(OH)24-oxo-D3 were identical with those of the natural product isolated from chick kidney incubates. The oxo compound showed biological activity similar to 24,25-dihydroxyvitamin D3 (24,25(OH...

BACKGROUND Deficiency in Vitamin D3 (cholecalciferol) may predispose to some malignancies, including gonadal tumors and in experimental models vitamin D3 has been proven to inhibit the growth of cancer cells. To learn more about the potential role of vitamin D3 in cancerogenesis, we evaluated the expression and functionality of the vitamin D receptor (VDR) and its role in metastasis of ovarian ...

abstract background and aims: vitamins are essential constituents of our diet that longley have been known to influence the immune system. vitamin d3 and b9 have received particular attention in recent years as these vitamins have been shown to have an unexpected and crucial effect on the immune response. 1, 25(oh)2d3 metabolizing enzymes and vitamin d receptor (vdr) are present in many cell ty...