A new chiral ligand, 2-(((1R,2R)-2-aminocyclohexyl)amino)acetic acid (HL), was designed and synthesized to prepare a series of novel dinuclear platinum(II) complexes with dicarboxylates or sulfate as bridges. The evaluation of these metal complexes in vitro cytotoxicity against human HCT-116, MCF-7 and HepG-2 cell lines were made. All compounds showed antitumor activity to HCT-116 and MCF-7. Pa...

Members of the globally important CTX-M group of extended-spectrum -lactamases fall into at least six subgroups (CTX-M-1, -2, -8, -9, -25, and KLUC [ 90% amino acid identity between subgroups]), with members of each subgroup differing by one or a few amino acid changes (1). Ancestral members of the different blaCTX-M subgroups appear to have been captured from the chromosomes of different Kluyv...

Anlotinib plus EGFR-TKIs continuation was a potential treatment strategy in selected advanced non-small cell lung cancer (NSCLC) after disease progression first-line EGFR-TKIs. This study aimed to evaluate the efficacy and safety of combined anlotinib. The trial enroll 120 patients gradual or local treatment. All were treated with oral anlotinib 12 mg daily for 14 days every three weeks until i...