The synthesis of cytochrome P-450c is induced remarkably in cultured cells as well as animal tissues in response to added chemicals such as 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzodioxin. To study this mechanism, we joined the sequence of 5'-flanking and upstream regions of the P-450c gene to the structural gene for chloramphenicol acetyltransferase. The fusion gene was introduced in...

High FVIII:C levels have previously been shown to be an independent risk factor for thrombosis with 4.8 times higher potential risk of thrombosis in individuals with FVIII:C levels greater than 1.5 u/ml. Recently, we found that raised FVIII:C levels are largely attributable to elevated FVIII:Ag levels. The determinants of FVIII:Ag levels are unclear and might be partly genetic. The promoter of ...

Allene (H2C═C═CH2; a-C3H4) and propyne (CH3C≡CH; p-C3H4) are important species in various chemical environments. In combustion processes, the reactions of hydroxyl radicals with a-C3H4 and p-C3H4 are critical in the overall fuel oxidation system. In this work, rate coefficients of OH radicals with allene (OH + H2C═C═CH2 → products) and propyne (OH + CH3C≡CH → products) were measured behind refl...

Abstract The search for habitable planets has revealed many that can vary greatly from an Earth analog environment. These include highly eccentric orbits, giant planets, different bulk densities, relatively active stars, and evolved stars. This work catalogs all found to reside in the zone (HZ) provides HZ boundaries, orbit characterization, potential spectroscopic follow-up observations. Demog...

Abstract Background There are currently some doubts about the efficacy of fractional flow reserve (FFR)-guided revascularization in different clinical settings. Aim To evaluate long-term outcome an FFR-deferred strategy daily practice. Methods The Clinical Outcome FFR-guided Revascularization Strategy Coronary Lesions (HALE-BOPP) is investigator-initiated, multicenter, international prospective...

Abstract Prosocial behaviors benefit others, but what benefits do they hold for those who enact them? Prosociality can enhance the actor’s well-being, yet whether it is one’s sense of happiness or meaning that impacted, and how this plays out in everyday life, has received limited attention. We address gap knowledge by examining prosociality related to daily across two large diary studies count...

BACKGROUNDS/AIMS We report our experience with day-surgery laparoscopic cholecystectomy and assess its feasibility and safety. METHODS Data was collected on all the patients who underwent day-surgery laparoscopic cholecystectomy between February 2009 and February 2014 at Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia. All patients had symptomatic cholelithiasis that was ...