Forty-two patients (28 men and 14 women) with acute myocardial infarction (35 Q, seven non-Q wave) were injected with 2.0 mCi indium 111-labeled antimyosin (AM) monoclonal antibody (111In AM) within 48 hours of the onset of chest pain. Forty-eight hours later (72-96 hours after onset of chest pain), patients were injected with 2.2 mCi thallium 201, and two sets of single-photon emission compute...

The high expression of somatostatin receptors in many tumours, have made receptor scintigraphy with 111In-DTPA-Octreotide a widly used procedure in nuclear medicine. Despite its clinical success, some limitation and drawbacks of radiolabelling with 111In remain, especially those concerned with the cost, availability and physical decay properties of this radionuclide. 99mTc-EDDA/HYNIC-Tyr3...

OBJECTIVE Carbonic anhydrase 9 recognized by chimeric monoclonal antibody cG250 is overexpressed on biliary cancers. The aim of this study was to determine the targeting of radiolabeled cG250 in patients with biliary cancer to explore a potential role of radioimmunotherapy. METHODS Three (3) patients received a diagnostic dose 111In-cG250, and images were acquired 2 hours and 5 days after inj...

The Pb(II) atom in the title compound, [Pb(C(10)H(8)NO)(2)], is chelated by two oxine (2-methyl-quinolin-8-olate) anions in a Ψ-trigonal-bipyramidal geometry; the N atoms occupy the axial sites. The mol-ecule lies about a twofold rotation axis.

Nuclear medical imaging is indicated in most, but not all, patients with suspected paragangliomas of the head and neck. Advances technology somatostatin receptor analogs have improved selectivity sensitivity this imaging. Paragangliomas are uncommon tumors neck that contain membrane-bound type 2 receptors (SSTR-2), making them easy to detect radiolabeled peptide Some these may present a typical...

Using data from 12 patients, we have analyzed the pharmacokinetics of 111In-9.2.27, an antimelanoma monoclonal antibody, following i.v. infusion. Plasma data and scintillation camera images obtained from patients receiving either 1, 50, or 100 mg of monoclonal antibody indicated dose-dependent (i.e., saturable) kinetics. Based on these observations and known immunoglobulin kinetics, we develope...

BACKGROUND Clinical trials indicate a beneficial effect of intracoronary infusion of progenitor cells on myocardial function in patients with ischemic heart disease. The extent and potential determinants of proangiogenic progenitor cell homing into the damaged myocardium after intracoronary infusion and the underlying mechanisms are still unknown. METHOD AND RESULTS Circulating proangiogenic ...