A single nervous system can generate many distinct motor patterns. Identifying which neurons and circuits control which behaviors has been a laborious piecemeal process, usually for one observer-defined behavior at a time. We present a fundamentally different approach to neuron-behavior mapping. We optogenetically activated 1054 identified neuron lines in Drosophila larvae and tracked the behav...

By means of Langevin molecular dynamics simulations, we study the packaging dynamics of flexible and semiflexible polyelectrolytes in spherical cavities that resemble viral capsids. We employ a coarse-grained model of the polymer– capsid complex that allows us to perform simulations of a 900mer and investigate the influence of surface charges inside the capsid and an additional motor force, act...

We present new VLA radio observations of a sample of dMe stars in X, U, K, and Q bands (from 8.4 to 43 GHz) obtained during an observing campaign in 1996 April-June. The aim of the project was to determine the spectral energy distributions of late-type dwarf flare stars to investigate the possible existence of an inversion of the spectrum slope at frequencies higher than 8 GHz. We also tried to...

T1 [ms] T2 [ms] M0 [a.U.] SE KWIC SE KWIC SE KWIC 1 1177 1054 1071 890 867 790 2,52 1,97 1,87 2 752 760 779 649 677 674 2,18 1,78 1,67 3 569 570 579 482 486 526 1,8 1,61 1,49 4 474 452 450 378 379 425 1,78 1,52 1,38 5 352 359 382 317 419 310 1,84 1,34 1,25 6 51 58 55 34 48 10 1,84 1,05 2,37 7 65 73 52 43 15 68 1,85 2,52 1,42 8 81 88 75 54 18 33 1,86 2,84 2,03 9 115 111 108 85 47 78 1,94 2,37 2,...

Fusion transcripts are products of chromosomal rearrangements that are frequently involved in carcinogenesis. A genomic translocation event can result in the fusion of two genes. The resulting chimeric gene is transcribed into a fusion transcript which in turn is translated into a fusion protein. In order to identify fusion transcripts systematically and comprehensively, we developed a pipeline...

du Hoffmann J, Kim JJ, Nicola SM. An inexpensive drivable cannulated microelectrode array for simultaneous unit recording and drug infusion in the same brain nucleus of behaving rats. J Neurophysiol 106: 1054–1064, 2011. First published May 25, 2011; doi:10.1152/jn.00349.2011.—Neurons are functionally segregated into discrete populations that perform specific computations. These computations, m...

OBJECTIVE Parasympathetic dysfunction is an independent risk factor in individuals with coronary artery disease, and cholinergic stimulation is a potential therapeutical option. We determined the effects of pyridostigmine bromide, a reversible anticholinesterase agent, on electrocardiographic variables of healthy individuals. METHODS We carried out a cross-sectional, double blind, randomized,...