نتایج جستجو برای: 103
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A 7-year-old boy with pica presented with a diagnosis of leukemia. He did not have hepatosplenomegaly, lymphadenopathy, or infection. Laboratory results were as follows: hemoglobin (Hb): 6.9 g/dL; mean corpuscular volume (MCV): 66 fL; red cell distribution width (RDW): 20.3%. Iron studies results were consistent with iron deficiency, as follows: serum iron: 13 μg/dL; total iron binding capacity...
We predict the spatial distribution and number of Milky Way dwarf galaxies to be discovered in the Dark Energy Survey (DES) and Large Synoptic Survey Telescope (LSST) surveys, by completeness correcting the observed Sloan Digital Sky Survey dwarf population. We apply most massive in the past, earliest forming, and earliest infall toy models to a set of dark matter-only simulated Milky Way/M31 h...
RATIONALE Necrosis is one of the main forms of cardiomyocyte death in heart disease. Recent studies have demonstrated that certain types of necrosis are regulated and programmed dependent on the activation of receptor-interacting serine/threonine-protein kinase (RIPK) 1 and 3 which may be negatively regulated by Fas-associated protein with death domain (FADD). In addition, microRNAs and long no...
MicroRNAs play extensive roles in cellular development. Analysis of the microRNA expression pattern during intestinal cell proliferation in early life is likely to unravel molecular mechanisms behind intestinal development and have implications for therapeutic intervention. In this study, we isolated mouse intestinal crypt cells, examined the differences in microRNA expression upon IGF-1 stimul...
Water-soluble polysaccharides isolated from the rhizome of Polygonatum sibiricum and fractionated using ion-exchange chromatography were investigated to determine their structure and immunostimulating activity. Crude and fractions (F1 and F2) consisted of carbohydrates (85.1~88.3%) with proteins (4.51~11.9%) and uronic acid (1.79~7.47%), and included different levels of mannose (62.3~76.3%), gl...
Although specific microRNAs (miRNAs) can be upregulated in cancer, global miRNA downregulation is a common trait of human malignancies. The mechanisms of this phenomenon and the advantages it affords remain poorly understood. Here we identify a microRNA family, miR-103/107, that attenuates miRNA biosynthesis by targeting Dicer, a key component of the miRNA processing machinery. In human breast ...
WILLIAM J. RIPPLE, GUILLAUME CHAPRON, JOSÉ VICENTE LÓPEZ-BAO, SARAH M. DURANT, DAVID W. MACDONALD, PETER A. LINDSEY, ELIZABETH L. BENNETT, ROBERT L. BESCHTA, JEREMY T. BRUSKOTTER, AHIMSA CAMPOS-ARCEIZ, RICHARD T. CORLETT, CHRIS T. DARIMONT, AMY J. DICKMAN, RODOLFO DIRZO, HOLLY T. DUBLIN, JAMES A. ESTES, KRISTOFFER T. EVERATT, MAURO GALETTI, VARUN R. GOSWAMI, MATT W. HAYWARD, SIMON HEDGES, MICHA...
Mailing Address: Claudio Gil Soares de Araújo • Clínica de Medicina do Exercício – CLINIMEX. Rua Siqueira Campos, 93/101, Copacabana. Postal Code 22071-030, Rio de Janeiro, RJ – Brazil E-mail: [email protected] Manuscript received September 15, 2015; revised manuscript September 15, 2015; accepted September 15, 2015.
Vibrio cholerae causes profuse, watery diarrhea, which may be life-threatening. The licensed parenteral vaccine has limited effectiveness and is not recommended for Canadians travelling to endemic areas. An oral cholera vaccine, CVD 103-HgR (Swiss Serum and Vaccine Institute), is available in Canada through the Emergency Drug Release Program of Health Canada. This brief evidence-based medicine ...
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