PURPOSE Secondarily generalized tonic-clonic seizures (SGTCS) are among the most devastating types of seizures, contributing to increased morbidity and mortality. Brivaracetam (BRV), a selective, high-affinity ligand for synaptic vesicle 2A (SV2A), has been shown to be useful for the adjunctive treatment of focal seizures. We sought to determine its specific efficacy in treating SGTCS. METHOD...

I'm sorry to say that there's hardly a word that is research based in this " 40 years hard labour " , but what surprises me is that my observation and experience is sometimes supported by subsequent research. This is an anecdotal account which I hope you will enjoy and find peppered with controversy, pearls of wisdom, and food for thought, but I expect it will not add one jot to the body of you...

This study was conducted to investigate the mitigation of dietary aflatoxin in Wistar rats using extract from selected phyto-antioxidant sources. A total one hundred and twenty weighing between 180-190g (80 females 40 males) at six weeks old were allotted eight treatments with 15 per treatment (10 5 males), a completely randomized design. The Treatment 1 (Normal diet + no aflatoxin), 2 (Aflatox...

Sundarijal River supply drinking water in Kathmandu city, Nepal and to study the nitrate concentration, 10 different sample from locations of was taken. The method for removal presence tested using hydroxylamine hydrochloride dose at 25±2 0C with 35 minutes contact time. Samples reduction increase increasing dosages, up certain limit. That mean 0.5g, 0.6g 0.8g dosages hydrochloride, not observe...

The incidence of myocardial infarction was found to be high among people of Indian origin who are living abroad. Disease of coronary artery is almost always due to atheroma and its complications. It is predicted that heart disease and stroke will become one of the leading causes of death and disability worldwide by the year 2020. The Materials And Methods were All Wistar strain male albino rats...

N H2 OMe Me 1/2 H2O The concentration and lung/serum ratio of DC-159a in CBA/JNCrlj mice were higher than those of MFLX, LVFX and gemifloxacin, described in Kurosaka et al. (the 46th ICAAC, poster No. F1-0489). As in the case of CBA/JNCrlj mice, DC-159a showed high concentrations in BALB/c mice after oral dosing. Accorded with the promising in vitro activity against M. tuberculosis isolates sho...

Although thalidomide is a U.S. Food and Drug Admistration (FDA) approved medication for erythema nodosum leprosum and multiple myeloma, it has many off-label uses, including for discoid lupus erythematosus (DLE), Behçet's disease, apththous ulcers in HIV patients, and prurigo nodularis. Herein, we present a patient with an overlap of discoid lupus erythematosus and lichen planus who was success...

Purpose There are three classes of HIV-1 based on diversity of the viral envelope: M (major), O (outlying) and N (new). The M group is subclassified into nine major subtypes including A—D, F—H, J and K, as well as several recombinant forms. There is a growing need to evaluate antiretroviral (ARV) treatment in these diverse subtypes. Methods M06-802 was an open-label, global, 48-week phase III t...

Common technologies for heavy metal removal are membrane separation, ion exchange, electro-deposition, and chemical precipitation. These methods prove to be costly and inept, especially in removing trace amounts of heavy metals [2]. Another disadvantage is the production of sludge or mud, which requires proper disposal and confi nement [3]. On the other hand, adsorption eff ectively removes con...

Amrithadi Churnam - a compound ayurvedic preparation made up of Tinospora cordifolia, Salacia prenoides, Curcuma longa, Tribulus terrestris and Emblica Officinalis was screened for its antidiabetic activity. From the studies it could be established that Amrithadi churnam at a dose level of 100mg/kg b.w. was the optimum dose in alloxan diabetic rats. No toxic effects were observed as evidenced b...