Although somatically mutated autoantibodies are characteristic of many autoimmune diseases, the processes that can lead to their development remain poorly understood. We have examined the formation of autoreactive memory B cells in PevHA mice, which express the influenza virus PR8 hemagglutinin (HA) as a transgenic membrane bound neo-self-Ag. Using a virus immunization strategy, we show that PR...

Environmental impacts of 15 European pig farming systems were evaluated in the European Union Q-PorkChains project using life cycle assessment. One conventional and two non-conventional systems were evaluated from each of the five countries: Denmark, The Netherlands, Spain, France and Germany. The data needed for calculations were obtained from surveys of 5 to 10 farms from each system. The sys...

+*Sakai, Y; * Matsuyama, Y; **Takahashi; **Sato, T; *Hattori, T; *Nakashima, S; *Ishiguro, N +* Nagoya University, Nagoya, Japan [email protected] Introduction: The achievement of peripheral nerve regeneration through biodegradable tubular conduits is at the frontier of nerve repair surgery. An ideal biodegradable conduit should maintain its structure integrity, nanostructured porous sc...

Influenza epidemics occur annually, and estimated 5-10% of the adult population and 20-30% of children will become ill from influenza infection. Seasonal vaccines primarily work through the induction of neutralizing antibodies against the principal surface antigen hemagglutinin (HA). This important role of HA-specific antibodies explains why previous pandemics have emerged when new HAs have app...

Transgenic expression of the influenza virus hemagglutinin (HA) in the pancreatic islet beta cells of InsHA mice leads to peripheral tolerance of HA-specific T cells. To examine the onset of tolerance, InsHA mice were immunized with influenza virus A/PR/8 at different ages, and the presence of nontolerant T cells was determined by the induction of autoimmune diabetes. The data revealed a neonat...

Minor histocompatibility Ags (mHags) are important targets of the graft-versus-leukemia effect after HLA-matched allogeneic stem cell transplantation. mHags are HLA-restricted polymorphic peptides expressed on normal and leukemia cells. Vaccination with hematopoiesis-restricted mHag peptides, such as HA-1, may boost the graft-versus-leukemia effect. However, some animal studies indicate that pe...

Purpose. To indentify the best shallot cultivars and local forms by growing period length, bulb yield, leaf productivity, weight number per clump in Right-Bank Forest-Steppe of Ukraine. Methods. Statistical processing, field assessments, computational analytical methods. Results. Collection accessions were evaluated for lengthand, weight, performance. Earlyripening accession ‘Sh-8’ with a veget...

BACKGROUND ATP-binding cassette transporter A1 (ABCA1) is a membrane integral protein which plays a vital role in High Density Lipoprotein (HDL) metabolism and exerts a protective effect against Hypoalphalipoproteinemia (HA) by mediation of rate-limiting step in HDL biogenesis. In addition, this protein possesses anti-inflammatory effects by inhibiting the production of some inflammatory cytoki...

A field experiment was carried out at Crop Research Farm, during Rabi 2021, Department of Agronomy, SHUATS, Prayagraj (Uttar Pradesh) to study the effects biofertilizers and potassium on yield economics yellow mustard. Biofertilizers (Azotobacter, Phosphate-Solubilizing Bacteria) Potassium levels (35, 40 45 kg/ha) were organized in a Randomized Block Design experiment. The treatment with Azotob...