Kalanchoe pinnata (KP) is popularly used for treating inflammatory diseases. This study investigated the antinociceptive, antiedematogenic, and anti-inflammatory potential of the subcutaneous administration of KP flower aqueous extract (KPFE), its ethyl acetate (EtOAcF) and butanol (BuOHF) fractions, and the main KP flavonoid [quercetin 3-O-α-L-arabinopyranosyl (1 → 2) α-L-rhamnopyranoside] (KP...

In this study, we examined whether several types of non-opioid agents would inhibit the pain-related responses of melanoma-bearing mice. Orthotopic inoculation with melanoma into the hind paw induced marked tactile allodynia and mechanical hyperalgesia. A peroral injection (p.o.) of gabapentin (100-300 mg/kg) inhibited the allodynia and hyperalgesia, without effects on gross behaviors. An intra...

Recommended dosages and durations of treatment are: up to 5000 mg/kg feed or 50 mg/kg bw to calves (oral administration) for up to 5 days; up to 50 mg/kg bw by intramuscular or intravenous injection to cattle, subdivided in two daily treatments for up to 7 days; up to 1000 mg/kg feed or 800 mg/l drinking water (up to 130 mg/kg bw) in poultry (oral administration) for up to 5 days; up to 70 mg/k...

OBJECTIVES Continued selective pressure from glycopeptide use has led to non-susceptible strains of Staphylococcus aureus, including vancomycin-intermediate S. aureus (VISA). Though relatively uncommon, VISA presents a particularly difficult clinical challenge when it arises. Pertinent to this investigation is the correlation between vancomycin intermediacy and daptomycin non-susceptibility. Th...

Introduction: We investigated the role of ATP-sensitive potassium channels and L-type calcium channels in morphine-induced hyperalgesia after nociceptive sensitization. Methods: We used a hotplate apparatus to assess pain behavior in male NMRI mice. Nociceptive sensitization was induced by three days injection of morphine and five days of drug free. On day 9 of the schedule, pain behavior te...

This study compared the anaesthetic effects of intramuscular injection of Ketamine (K) (15 mg/kg) with intramuscular injection of Ketamine (K) (15 mg/kg) and Lignocaine (L) (4 mg/kg) infiltration for laparocaecectomy in 12 layer chickens (1.1±0.06 Kg) randomized into two groups (K, 5 chickens and KL, 7 chickens). The duration of recumbency of the K-L group (100.3±16.4 min) was significantly lon...

Melatonin, a pineal hormone, is also produced in the gastrointestinal tract. Melatonin receptors have been detected in the stomach, intestine and pancreas. This indole inhibits insulin secretion but its role in the physiological modulation of exocrine pancreatic function is yet unknown. The aim of this study was to evaluate the pancreatic secretory effect of melatonin and its precursor; L-trypt...

Effects of Hyoscyamus niger L on central nervous system have been known for many years. The effects of methanolic extract of H. niger L. on seizures induced by picrotoxin was studied in mice in this investigation. In this study 7 groups of animals pretreated with methanolic extract of the plant (12.5, 25, 50, 100, 200, 300, 400 mg/kg/i.p.), 20 minutes prior to the picrotoxin (12 mg/kg/ i.p.)--i...

AIM To investigate the involvement of L-type Ca(2+) channels in antinociceptive action induced by the 5-HT precursor, 5-hydroxytryptophan (5-HTP). METHODS Female Kunming mice were treated with either 5-HTP (20-80 mg/kg, ip) alone, or the combination of 5-HTP and fluoxetine (2-8 mg/kg, ip), pargyline (15-60 mg/kg, ip), nimodipine (2.5-10 mg/kg, ip), nifedipine (2.5-10 mg/kg, ip), verapamil (2....