نتایج جستجو برای: 10 dione derivatives

تعداد نتایج: 1117760  

2016
María del Mar Roldán García María Jesús García-Godoy José Francisco Aldana Montes

BACKGROUND Systematized Nomenclature of Medicine - Clinical Terms (SNOMED CT) has been designed as standard clinical terminology for annotating Electronic Health Records (EHRs). EHRs textual information is used to classify patients' diseases into an International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) category (usually by an expert). Improving the accuracy...

Journal: :Düzce Üniversitesi bilim ve teknoloji dergisi 2021

An efficient green approach for the synthesis of 9-heteroaryl-acridine-1,8-dione derivatives (3a-f) was accomplished via reactions dimedone (1) with various heteroaromatic aldehydes (2a-f) and ammonium acetate through one-pot multicomponent in water under mild conditions using ultrasound irradiation excellent yields. Of synthesized compounds, 3d-f were novel this process presents advantages hig...

Journal: :Oriental journal of chemistry 2023

Herein, we report the synthesis of novel thiazo-isoindolinedione derivatives in excellent yields (up to 92%) from reaction thiazolidinedione and isoindoline-dione. The structures compounds were elucidated by 1H-, 13C-NMR, MS analyses. Furthermore, molecular docking analysis was performed study potential inhibition SARS-CoV-2 main protease (Mpro) new thiazo-isoindolinediones. present revealed th...

2012
Nikolay T Tzvetkov Harald Euler Christa E Müller

Dihydroimidazo[5,1-c][1,2,4]triazine-3,6(2H,4H)-dione derivatives were prepared by successive N3- and N1-alkylation of hydantoins, followed by regioselective thionation and subsequent cyclization under mild conditions. In a final alkylation step a further substituent may be introduced. The synthetic strategy allows broad structural variation of this new drug-like heterobicyclic scaffold. In add...

2015
Brett D. Schwartz Mark J. Coster Tina S. Skinner-Adams Katherine T. Andrews Jonathan M. White Rohan A. Davis Sylvia Urban

Six regioisomers associated with the tricyclic core of thiaplakortones A-D have been synthesized. Reaction of 1H-indole-4,7-dione and 1-tosyl-1H-indole-4,7-dione with 2-aminoethanesulfinic acid afforded a regioisomeric series, which was subsequently deprotected and oxidized to yield the tricyclic core scaffolds present in the thiaplakortones. All compounds were fully characterized using NMR and...

Journal: :Journal of advanced scientific research 2021

Isatin, also known as 1H-Indole-2, 3-Dione, is an eight-carbon containing endogenous compound found in nature. Erdmann and Laurent synthesized isatin 1840, before it was discovered It versatile distributed tissues body fluids. Isatins have been detected mammalian tissue, their function a biochemical process modulator has the focus of many debates. The moiety shows some important chemical reacti...

2005
EUAN H. D. CAMERON

The localization and some characteristics of mouse adrenal C19-steroid 5fi-reductase were determined by the incubation of subcellular fractions of mouse adrenal tissue with [7a-3H]androst-4-ene-3,17-dione. This enzyme was present only in the soluble fraction and was NADPH-dependent, although a small activity in the presence ofNADH was also detected. The soluble fraction also contained 3 a-, 3,6...

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